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Towards the Understanding a Metal-Tumour-Metabolism

Publications

Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape

Author(s): Qinghua Wu; Li You; Eugenie Nepovimova; Zbynek Heger; Wenda Wu; Kamil Kuca; Vojtech Adam
Published in: Journal of Hematology & Oncology, Issue vol. 15, issue 1, 2022, Page(s) 1-18, ISSN 1756-8722
Publisher: BioMed Central
DOI: 10.1186/s13045-022-01292-6

Homology modeling in the time of collective and artificial intelligence

Author(s): HAMEDUH; Tareq; Yazan Abdulmajeed Eyadh HADDAD; Vojtěch ADAM; Zbyněk HEGER
Published in: Computational and Structural Biotechnology Journal, Issue vol. 18, issue 1, 2021, Page(s) 3494-3506, ISSN 2001-0370
Publisher: Elsevier
DOI: 10.1016/j.csbj.2020.11.007

The Anti-Proliferative Activity of Coordination Compound-Based ZnO Nanoparticles as a Promising Agent Against Triple Negative Breast Cancer Cells

Author(s): Stepankova H; Swiatkowski M; Kruszynski R; Svec P; Michalkova H; Smolikova V; Ridoskova A; Splichal Z; Michalek P; Richtera L; Kopel P; Adam V; Heger Z; Rex S;
Published in: International Journal of Nanomedicine, Issue vol. 16, issue 1, 2021, Page(s) 4431-4449, ISSN 1178-2013
Publisher: Dove Press
DOI: 10.2147/ijn.s304902

Metallothionein dimerization evidenced by QD-based Förster resonance energy transfer and capillary electrophoresis

Author(s): PAVELICOVÁ, K.; POMPEIANO VANÍČKOVÁ, L.; HADDAD, Y.; NEJDL, L.; ZÍTKA, J.; KOČIOVÁ, S.; MRAVEC, F.; VACULOVIČ, T.; MACKA, M.; VACULOVIČOVÁ, M.; ADAM, V.
Published in: International Journal of Biological Macromolecules, Issue Volume 170, 2021, Page(s) 53-60, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2020.12.105

Metal- and Affinity-Specific Dual Labeling of Cysteine-Rich Proteins for Identification of Metal-Binding Sites

Author(s): Manuel David Peris-Díaz, Roman Guran, Ondrej Zitka, Vojtech Adam, Artur Krężel
Published in: Analytical Chemistry, Issue 92/19, 2020, Page(s) 12950-12958, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.0c01604

Metallothionein-3 promotes cisplatin chemoresistance remodelling in neuroblastoma

Author(s): Miguel Angel Merlos Rodrigo, Hana Michalkova, Vladislav Strmiska, Berta Casar, Piero Crespo, Vivian de los Rios, J. Ignacio Casal, Yazan Haddad, Roman Guran, Tomas Eckschlager, Petra Pokorna, Zbynek Heger, Vojtech Adam
Published in: Scientific Report, Issue vol. 11, issue 1, 2021, Page(s) 1-14, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-84185-x

Mass Spectrometry-Based Structural Analysis of Cysteine-Rich Metal-Binding Sites in Proteins with MetaOdysseus R Software

Author(s): Manuel David Peris-Díaz, Roman Guran, Ondrej Zitka, Vojtech Adam, Artur Krężel
Published in: Journal of Proteome Research, 2020, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.0c00651

Proteomic Signature of Neuroblastoma Cells UKF-NB-4 Reveals Key Role of Lysosomal Sequestration and the Proteasome Complex in Acquiring Chemoresistance to Cisplatin

Author(s): Miguel Angel Merlos Rodrigo, Hana Buchtelova, Vivian de los Rios, José Ignacio Casal, Tomas Eckschlager, Jan Hrabeta, Marie Belhajova, Zbynek Heger, Vojtech Adam
Published in: Journal of Proteome Research, Issue 18/3, 2019, Page(s) 1255-1263, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.8b00867

Molecularly imprinted polymers coupled to mass spectrometric detection for metallothionein sensing

Author(s): Tereza Vaneckova, Lucie Vanickova, Michaela Tvrdonova, Adam Pomorski, Artur Krężel, Tomas Vaculovic, Viktor Kanicky, Marketa Vaculovicova, Vojtech Adam
Published in: Talanta, Issue 198, 2019, Page(s) 224-229, ISSN 0039-9140
Publisher: Elsevier BV
DOI: 10.1016/j.talanta.2019.01.089

Transcriptomic Landscape of Cisplatin-Resistant Neuroblastoma Cells

Author(s): Miguel Rodrigo, Hana Buchtelova, Ana Jimenez, Pavlina Adam, Petr Babula, Zbynek Heger, Vojtech Adam
Published in: Cells, Issue 8/3, 2019, Page(s) 235, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells8030235

Mass spectrometric imaging of cysteine rich proteins in human skin

Author(s): Lucie Vanickova, Roman Guran, Sándor Kollár, Gabriella Emri, Sona Krizkova, Tomas Do, Zbynek Heger, Ondrej Zitka, Vojtech Adam
Published in: International Journal of Biological Macromolecules, Issue 125, 2019, Page(s) 270-277, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2018.11.272

Rotamer Dynamics: Analysis of Rotamers in Molecular Dynamics Simulations of Proteins

Author(s): Yazan Haddad, Vojtech Adam, Zbynek Heger
Published in: Biophysical Journal, Issue 116/11, 2019, Page(s) 2062-2072, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2019.04.017

Ten quick tips for homology modeling of high-resolution protein 3D structures

Author(s): Yazan Haddad, Vojtech Adam, Zbynek Heger
Published in: PLOS Computational Biology, Issue 16/4, 2020, Page(s) e1007449, ISSN 1553-7358
Publisher: PLOS Computational Biology
DOI: 10.1371/journal.pcbi.1007449

A chemometric-assisted voltammetric analysis of free and Zn(II)-loaded metallothionein-3 states

Author(s): Manuel David Peris-Díaz, Lukas Richtera, Ondrej Zitka, Artur Krężel, Vojtech Adam
Published in: Bioelectrochemistry, Issue 134, 2020, Page(s) 107501, ISSN 1567-5394
Publisher: Elsevier BV
DOI: 10.1016/j.bioelechem.2020.107501

Metallothionein isoforms as double agents – Their roles in carcinogenesis, cancer progression and chemoresistance

Author(s): Miguel Angel Merlos Rodrigo, Ana Maria Jimenez Jimemez, Yazan Haddad, Khaldon Bodoor, Pavlina Adam, Sona Krizkova, Zbynek Heger, Vojtech Adam
Published in: Drug Resistance Updates, Issue 52, 2020, Page(s) 100691, ISSN 1368-7646
Publisher: Churchill Livingstone
DOI: 10.1016/j.drup.2020.100691

Efficient Protein Transfection by Swarms of Chemically Powered Plasmonic Virus-Sized Nanorobots

Author(s): Alzbeta Ressnerova, Filip Novotny, Hana Michalkova, Martin Pumera, Vojtech Adam, Zbynek Heger
Published in: ACS Nano, Issue vol. 15, issue 8, 2021, Page(s) p. 12899-12910, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.1c01172

Signal Transducer and Activator of Transcription 3 Signaling in Tumor Immune Evasion

Author(s): Zhang, Luying; Kuča, Kamil; You, Li; Zhao, Yingying; Musílek, Kamil; Nepovimová, Eugenie; Wu, Qinghua; Wu, Wenda; Adam, Vojtěch
Published in: PHARMACOLOGY & THERAPEUTICS, Issue vol. 230, issue 1, 2022, Page(s) 1-11, ISSN 0163-7258
Publisher: Pergamon Press
DOI: 10.1016/j.pharmthera.2021.107969

A rotamer relay information system in the epidermal growth factor receptor-drug complexes reveals clues to new paradigm in protein conformational change.

Author(s): Tareq Hameduh; Michal Mokry; Michal Mokry; Andrew D. Miller; Vojtech Adam; Vojtech Adam; Zbynek Heger; Zbynek Heger; Yazan Haddad; Yazan Haddad
Published in: Computational and Structural Biotechnology Journal, Issue vol. 19, issue 1, 2021, Page(s) 5443-5454, ISSN 2001-0370
Publisher: Elsevier
DOI: 10.1016/j.csbj.2021.09.026

Extending the Applicability of In Ovo and Ex Ovo Chicken Chorioallantoic Membrane Assays to Study Cytostatic Activity in Neuroblastoma Cells.

Author(s): Miguel Angel Merlos Rodrigo; Miguel Angel Merlos Rodrigo; Berta Casar; Berta Casar; Hana Michalkova; Hana Michalkova; Ana Maria Jimenez Jimenez; Ana Maria Jimenez Jimenez; Zbynek Heger; Zbynek Heger; Vojtech Adam; Vojtech Adam
Published in: Frontiers in Oncology, Vol 11, Issue vol. 11, issue 9, 2021, Page(s) 1-10, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.707366

The role of hypoxia-inducible factor 1 in tumor immune evasion.

Author(s): Li You; Wenda Wu; Wenda Wu; Xu Wang; Liurong Fang; Vojtech Adam; Vojtech Adam; Eugenie Nepovimova; Qinghua Wu; Qinghua Wu; Kamil Kuca
Published in: MEDICINAL RESEARCH REVIEWS, Issue vol. 41, issue 3, 2021, Page(s) p. 1622-1643, ISSN 0198-6325
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/med.21771

An Integrated Mass Spectrometry and Molecular Dynamics Simulations Approach Reveals the Spatial Organization Impact of Metal-Binding Sites on the Stability of Metal-Depleted Metallothionein-2 Species.

Author(s): Manuel David Peris-Díaz; Roman Guran; Roman Guran; Carmen Domene; Carmen Domene; Vivian de los Ríos; Ondrej Zitka; Ondrej Zitka; Vojtech Adam; Vojtech Adam; Artur Krężel
Published in: Journal of the American Chemical Society, Issue vol. 143, issue 40, 2021, Page(s) 16486-16501, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c05495

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