Objective
Idiopathic Pulmonary Fibrosis (IPF) is a relentlessly progressive, lethal, lung disease with a uniquely poor prognosis. Patients typically die within 2-5years of diagnosis and IPF’s European incidence is increasing while effective therapies for improving survival remain elusive.
IPF is a disease in which the normal wound healing responses are dysregulated leading to fibrosis and loss of gas-exchange regions in the lung rather than restoration of normal lung structure and function. Recently discovered invasive fibroblasts are believed to be central to the progressive fibrogenesis observed in IPF by contributing to an accumulation of fibroblasts in the injured lung and augmenting the destruction of normal alveolar structure. However the source of these invasive fibroblasts and what makes them so uniquely pathogenic is unknown.
On this project I will work with Prof. Paul Noble, Cedars-Sinai Medical Centre, USA, one of the world’s leading IPF researchers and Ireland’s leading respiratory researcher Prof. Paul McLoughlin, University College Dublin, Ireland. The objectives of this project are to investigate: (1) the phenotype and behaviour of the invasive fibroblast from human IPF donors in vitro; (2) delineate the molecular pathways that make invasive human IPF fibroblasts uniquely pathogenic using state-of-the-art single cell RNA-sequencing; (3) determine the source of invasive fibroblast accumulation in the IPF lung using the most advanced lineage tracing methods available in a cutting-edge genetically modified mouse model.
This interdisciplinary proposal will merge skills I have acquired with the latest technologies across multiple disciplines in world leading international institutions to explore the complex molecular basis of IPF. The results of this proposal will generate significant impact in the IPF field and will be directly applicable to the specific challenge highlighted in the H2020 Work Programme: Diagnostic characterisation of rare diseases.
Fields of science (EuroSciVoc)
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
4 Dublin
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.