Objective
Childhood psychiatric disorders are alarmingly common, yet current gold-standard treatments fall short in creating lasting, meaningful improvements for many individuals. To improve outcomes, it is imperative to enhance our understanding of pathways to disordered development. Recent advances in the study of microglia-neuron interactions and critical period signals suggest that disruption in the developmental timing of these neural events may contribute to early-onset psychopathology. However, the factors that modulate these signals have not been well-defined. The GutMIND project will test the hypothesis that complementary maturation of the microbiota and the brain during critical windows of development may be one contributing factor. For the first time, the (sex-specific) trajectory of the microbiota’s influence on behavioural and neural outcomes during early host development will be characterised in detail. This will generate testable hypotheses regarding potential mechanisms and thus potential treatments to ameliorate the effects of microbiota depletion during critical periods. Specifically, this will be achieved by experimentally testing 1) metabolite pathways that may contribute to the microbiota’s influence on microglia-neuron communication and 2) the mediating role of the microglia in microbial influences on behaviour. In line with the objectives of the MSCA fellowships, the research project has been designed to facilitate the applicant’s career development by providing advanced training in supportive host environments that will diversify her research competencies, foster her managerial and teaching skills, and strengthen her research profile and professional network. In the process, public, industry, and scientific audiences will be engaged in the outcomes of the action through a multi-pronged communication, dissemination, & exploitation strategy that will promote positive mental health development in the EU and beyond.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
T12 YN60 Cork
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.