Objective
Population in developed countries is aging. Besides other socioeconomic effects, this significantly affects European health systems, as ageing-specific therapies and treatments have become important cost factors. In this context, hip replacements belong to one of the most frequent and costly treatments. Recent reports on mass failures of new types of hip prosthesis revealed insufficient understanding of physiological processes leading to prosthesis failure. Studies on hip prosthesis failures revealed complex processes leading to chemical degradation of implants, resulting in desorbed elements and ions entering the surrounding tissue, causing inflammation and loosening of hip prosthesis. The research needed to reveal important details of the body response to the implant is lacking of the incorporation of novel techniques and approaches.
Techniques currently applied in hospitals, such as X-ray scans and optical tissue microscopies do not fully explain the effects of implants on the body physiology. Moreover, the screening of new types of implants before its introduction into clinic processes may lack of scientific understanding of possible destructive effects. Modern tissue microscopy techniques are promising providing elemental and chemical distribution of a tissue, with high sensitivities and lateral resolution. Micro Proton Induced X-ray Emission (microPIXE) allows determining the quantitative elemental mapping of a tissue and has been proved to be the best technique for element localization studies in biological tissues due to its capability of analysing at sub-cellular level the distribution of elements incorporated to biological tissue, due to a high sensitivity ranging down to 0.1 ppm level.
The action will focus on investigating reasons of failures and rejections of hip replacements by application of advanced elemental microscopies to human tissue surrounding hip failures. Results may determine the origin of failure and avoid prosthesis rejection.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences optics microscopy
- medical and health sciences basic medicine physiology
- medical and health sciences medical biotechnology implants
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-CAR - CAR – Career Restart panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1000 Ljubljana
Slovenia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.