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Improving the care of patients suffering from acute or chronic pain

Deliverables

Publications

IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the efects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity

Author(s): Leone, Caterina Maria; Di Stefano, Giulia; Di Pietro, Giuseppe; Bloms-Funke, Petra; Boesls, Irmgrad; Caspani, Ombretta; Chapman, Sonya C; Finnerup, Nanna Brix; Garcia-Larrea, Luis; Li, Tom; Goetz, Marcus; Mouraux, André; Pelz, Bernhard; Pogatzki-Zahn,Esther; Schilder, Andreas; Schnetter, Erik; Schubart, Karin; Tracey, Irene; Troconiz, Inaki F; Van Niel, Hans; Vela Hernandez, Josè Miguel; Vincent
Published in: Trials, Issue 3, 2022, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/s13063-022-06431-5

Paravertebral block for the prevention of chronic postsurgical pain after breast cancer surgery

Author(s): Hakim Harkouk, Dominique Fletcher, Valeria Martinez
Published in: Regional Anesthesia & Pain Medicine, Issue 46/3, 2021, Page(s) 251-257, ISSN 1098-7339
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1136/rapm-2020-102040

Comprehensive quantitative sensory testing shows altered sensory function in women with chronic pelvic pain: results from the Translational Research in Pelvic Pain (TRiPP) Study.

Author(s): Coxon, Lydiaa,*; Vollert, Janb,c,d,e; Perro, Daniellea; Lunde, Claire E.a,f,g; Ferreira-Gomes, Joanah; Charrua, Anah; Abreu-Mendes, Pedroh; Krassowski, Michala; Birch, Judyi; Meijlink, Janej; Hummelshoj, Lonek; Hoffmann, Anjal; Aziz, Qasimm; Arendt-Nielsen, Larsn,o; Pogatzki-Zahn, Estherb; Evans, Emmaa; Demetriou, Lysiaa; McMahon, Stephen B.p; Missmer, Stacey A.q,r,s; Becker, Christian M.a; Zonder
Published in: Pain, 2023, ISSN 0304-3959
Publisher: Elsevier BV
DOI: 10.1097/j.pain.0000000000002955

The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models

Author(s): Ana Catarina Neto,Mariana Santos-Pereira,Pedro Abreu-Mendes,Delminda Neves,Henrique Almeida,Francisco Cruz andAna Charrua
Published in: Biomedicines, 2023, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines11030696

Developing consensus on core outcome domains and measurement instruments for assessing effectiveness in perioperative pain management after sternotomy, breast cancer surgery, total knee arthroplasty, and surgery related to endometriosis

Author(s): Ulrike Kaiser, Hiltrud Liedgens, Winfried Meissner, Claudia Weinmann, Peter Zahn, Esther Pogatzki-Zahn
Published in: Trials, Issue 21/1, 2020, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/s13063-020-04665-9

Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans

Author(s): A. Di Lionardo, G. Di Stefano, C. Leone, G. Di Pietro, E. Sgro, E. Malara, C. Cosentino, C. Mollica, A. J. Blockeel, O. Caspani, L. Garcia-Larrea, A. Mouraux, R. D. Treede, K. G. Phillips, M. Valeriani & Andrea Truini
Published in: Scientific reports, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-00313-7

How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex

Author(s): Leone C, Di Lionardo A, Di Pietro G, Di Stefano G, Falco P, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Phillips KG, Treede RD, Truini A.
Published in: Clin Neurophysiol ., 2021, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2021.08.018

Association of sensory phenotype with quality of life, functionality, and emotional well-being in patients suffering from neuropathic pain

Author(s): Gierthmühlen, Jannea,*; Böhmer, Johanna; Attal, Nadineb; Bouhassira, Didierb; Freynhagen, Rainerc,d; Haanpää, Maijae; Hansson, Perf,g; Jensen, Troels Staehelinh; Kennedy, Jeffreyi; Maier, Christophj; Rice, Andrew S.C.k; Sachau, Julianea; Segerdahl, Märtal; Sindrup, Sörenm; Tölle, Thomasn; Treede, Rolf-Detlefo; Ventzel, Lisef,p; Vollert, Jana,o; Baron, Ralfa
Published in: Pain, 2021, ISSN 0304-3959
Publisher: Elsevier BV
DOI: 10.1097/j.pain.0000000000002501

Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome

Author(s): Paulina Nunez-Badinez, Bianca De Leo, Alexis Laux-Biehlmann, Anja Hoffmann, Thomas M. Zollner, Philippa T.K. Saunders, Ioannis Simitsidellis, Ana Charrua, Francisco Cruz, Raul Gomez, Miguel Angel Tejada, Stephen B. McMahon, Laure Lo Re, Florent Barthas, Katy Vincent, Judy Birch, Jane Meijlink, Lone Hummelshoj, Patrick J. Sweeney, J. Douglas Armstrong, Rolf-Detlef Treede, Jens Nagel
Published in: Pain, Issue Publish Ahead of Print, 2021, Page(s) 2021, ISSN 0304-3959
Publisher: Elsevier BV
DOI: 10.1097/j.pain.0000000000002248

Patient reported outcome measures in chronic neuropathic pain clinical trials - a systematic literature review.

Author(s): Sachau J, Sendel M, Péchard M, Schnabel K, Schmieg I, Medkour T, Ecochard L, Woischnik M, Liedgens H, Pogatzki-Zahn E, Baron R, Bouhassira D.
Published in: The journal of pain, 2022, ISSN 1526-5900
Publisher: Churchill Livingstone
DOI: 10.1016/j.jpain.2022.09.003

Human surrogate models of central sensitization: A critical review and practical guide

Author(s): Charles Quesada, Anna Kostenko, Idy Ho, Caterina Leone, Zahra Nochi, Alexandre Stouffs, Matthias Wittayer, Ombretta Caspani, Nanna Brix Finnerup, André Mouraux, Gisèle Pickering, Irene Tracey, Andrea Truini, Rolf‐Detlef Treede, Luis Garcia‐Larrea
Published in: European Journal of Pain, 2021, ISSN 1090-3801
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1002/ejp.1768

IMI-PAINCARE, BIOPAIN : validation chez l’homme de nouveaux biomarqueurs fonctionnels pour le développement pharmacologique de traitements de la douleur

Author(s): A. Stouffs, L. Lebrun, A. Mouraux
Published in: Douleur et Analgésie, Issue 31/4, 2018, Page(s) 230-231, ISSN 1011-288X
Publisher: Editions Medecine et Hygiene
DOI: 10.3166/dea-2018-0041

Urinary bladder sigma-1 receptors: A new target for cystitis treatment

Author(s): Rafael González-Cano, Antonia Artacho-Cordón, Lucía Romero, Miguel A. Tejada, Francisco R. Nieto, Manuel Merlos, Francisco J. Cañizares, Cruz M. Cendán, Eduardo Fernández-Segura, José M. Baeyens
Published in: Pharmacological Research, Issue 155, 2020, Page(s) 104724, ISSN 1043-6618
Publisher: Academic Press
DOI: 10.1016/j.phrs.2020.104724

Effect of Water Avoidance Stress on serum and urinary NGF levels in rats: diagnostic and therapeutic implications for BPS/IC patients

Author(s): Bruno Dias, Paula Serrão, Francisco Cruz, Ana Charrua
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-50576-4

Rodent Animal Models of Endometriosis-Associated Pain: Unmet Needs and Resources Available for Improving Translational Research in Endometriosis.

Author(s): Tejada, M. A., Antunez, C., Nunez-Badinez, P., De Leo, B., Saunders, P. T., Vincent, K., Cano, A., Nagel, J., & Gomez, R.
Published in: International journal of molecular sciences, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24032422

The N13 spinal component of somatosensory evoked potentials is modulated by heterotopic noxious conditioning stimulation suggesting an involvement of spinal wide dynamic range neurons

Author(s): Pietro GD, Stefano GD, Leone C, Lionardo AD, Sgrò E, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Phillips KG, Treede RD, Valeriani M, Truini A.
Published in: Neurophysiologie Clinique, 2021, ISSN 0987-7053
Publisher: Elsevier Masson
DOI: 10.1016/j.neucli.2021.09.001

Clinical profiling of specific diagnostic subgroups of women with chronic pelvic pain.

Author(s): Lysia Demetriou, Michal Krassowski, Pedro Abreu Mendes, Kurtis Garbutt, Allison F. Vitonis, Elizabeth Wilkins, Lydia Coxon, Lars Arendt-Nielsen, Qasim Aziz, Judy Birc, Andrew W. Horne, Anja Hoffman, Lone Hummelshoj, Claire E. Lunde, Jane Meijlink, Danielle Perro, Nilufer Rahmioglu, Kathryn L. Terry, Esther Pogatzki-Zahn, Christine B. Sieberg, Rolf-Detlef Treede, Christian M. Becker, Francisco Cruz
Published in: Frontiers in Reproductive Health, 2023, ISSN 2673-3153
Publisher: Lausanne Frontiers Media SA [2020]-
DOI: 10.3389/frph.2023.1140857

INTEGRATE-Pain: a transatlantic consortium to advance development of effective pain management

Author(s): Laura D Wandner, PhD, Petra Bloms-Funke, PhD, Giulia Bova, MA, Anthony Domenichiello, PhD, Anja Hoffmann, MD, Smriti Iyengar, PhD, Barbara I Karp, MD, Janelle Letzen, PhD, Hiltrud Liedgens, PhD, Durga P Mohapatra, PhD, Jens Nagel, PhD, Mary Ann Pelleymounter, PhD, Esther Pogatzki-Zahn, MD, Leah Pogorzala, PhD, Jan Vollert, PhD, Sarah A Woller, PhD, Rolf-Detlef Treede, MD
Published in: Pain Medicine, 2023, ISSN 1526-4637
Publisher: American Academy of Pain Medicine
DOI: 10.1093/pm/pnad033

Developing consensus on core outcome domains for assessing effectiveness in perioperative pain management

Author(s): Esther M. Pogatzki-Zahn, Hiltrud Liedgens, Lone Hummelshoj, Winfried Meissner, Claudia Weinmann, Rolf-Detlef Treede, Katy Vincent, Peter Zahn, Ulrike Kaiser
Published in: Pain, Issue Publish Ahead of Print, 2021, Page(s) 2021, ISSN 0304-3959
Publisher: Elsevier BV
DOI: 10.1097/j.pain.0000000000002254

IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG)

Author(s): André Mouraux, Petra Bloms-Funke, Irmgard Boesl, Ombretta Caspani, Sonya C. Chapman, Giulia Di Stefano, Nanna Brix Finnerup, Luis Garcia-Larrea, Marcus Goetz, Anna Kostenko, Bernhard Pelz, Esther Pogatzki-Zahn, Karin Schubart, Alexandre Stouffs, Andrea Truini, Irene Tracey, Iñaki F. Troconiz, Johannes Van Niel, Jose Miguel Vela, Katy Vincent, Jan Vollert, Vishvarani Wanigasekera, Matthias Wittay
Published in: Trials, Issue 22/1, 2021, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/s13063-021-05272-y

The test-retest reliability of large and small fiber nerve excitability testing with threshold tracking.

Author(s): Pia H, Nochi Z, Kristensen AG, Pelz B, Goetz M, Hoeink JN, Blockeel AJ, Mouraux A, Truini A, Finnerup NB, Phillips KG, Treede RD, Tankisi H.
Published in: Clinical neurophysiology practice, 2023, ISSN 2467-981X
Publisher: Elsevier B.V.
DOI: 10.1016/j.cnp.2023.03.003

Pharmacological Probes to Validate Biomarkers for Analgesic Drug Development.

Author(s): van Niel J, Bloms-Funke P, Caspani O, Cendros JM, Garcia-Larrea L, Truini A, Tracey I, Chapman SC, Marco-Ariño N, Troconiz IF, Phillips K, Finnerup NB, Mouraux A, Treede R-D
Published in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23158295

Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain.

Author(s): Tejada MA, Santos-Llamas AI, Escriva L, Tarin JJ, Cano A, Fernández-Ramírez MJ, Nunez-Badinez P, De Leo B, Saunders PTK, Vidal V, Barthas F, Vincent K, Sweeney PJ, Sillito RR, Armstrong JD, Nagel J, Gomez R.
Published in: Biomedicines, 2022, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines10020501

IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET).

Author(s): Nochi Z, Pia H, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Fardo F, Genser B, Goetz M, Kostenko AV, Leone C, Li T, Mouraux A, Pelz B, Pogatzki-Zahn E, Schilder A, Schnetter E, Schubart K, Stouffs A, Tracey I, Troconiz IF, Truini A, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Tankisi H, Finnerup NB, Phillips KG, Treede RD.
Published in: Trials, 2022, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/s13063-022-06087-1

Pre-clinical models of endometriosis and their value for translational research.

Author(s): P. Nunez-Badinez
Published in: Drug Target Review, 2022
Publisher: Russell Publishing Ltd.

New approach in research on two pelvic pain disorders

Author(s): Paulina Nunez-Badinez, Judy Birch, Lydia Coxon
Published in: 2020
Publisher: Mediaplanet

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