Improving the care of patients suffering from acute or chronic pain

Leistungen

Review of clinical and preclinical literature on biomarkers and medication

INSERM-B/GRT

Study design proposal for using validated biomarkers in clinical trials in patients

Consensus on final trial designs for BioPainRCT1, BioPainRCT2, BioPainRCT3 and BioPainRCT4

UHEI/GRT

Report on the INTEGRATE-Pain Consortium Meeting in Aug 2020

Report on the virtual INTEGRATEPain meeting in August 2020 together with the NIHHEAL initiative

White Book publication/submission

LEAD UHEI GRT

Characterization of the standardized PROMs for chronic pain, mirroring pain state as well as cognitive and functional consequences for use in clinical practice and communication by the expert panel

LEAD CAU INSERMP

Report on status of posting WP2 results (PROMPT-NIT1)

PROMs consensus for use in clinical practice / hospitals, and in RCTs, for post-operative pain

LEAD WWW GRT

EMA guidance document submitted

Translational evaluation of biomarker response in different compartments of the nociceptive system at clinically effective concentrations

LEAD UHEIUNAV

Visualization of results of PROM-NIT1 for feedback to participating hospitals

Complete set up of all primary biomarkers

Study synopsis and protocol uploaded to EudraCT

AU, GRT

Publication of test-retest reliability and site-to-site reproducibility of biomarker results

LEAD UHEI LIL

Website and social media account set-up

Veröffentlichungen

IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the efects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity

Autoren: Leone, Caterina Maria; Di Stefano, Giulia; Di Pietro, Giuseppe; Bloms-Funke, Petra; Boesls, Irmgrad; Caspani, Ombretta; Chapman, Sonya C; Finnerup, Nanna Brix; Garcia-Larrea, Luis; Li, Tom; Goetz, Marcus; Mouraux, André; Pelz, Bernhard; Pogatzki-Zahn,Esther; Schilder, Andreas; Schnetter, Erik; Schubart, Karin; Tracey, Irene; Troconiz, Inaki F; Van Niel, Hans; Vela Hernandez, Josè Miguel; Vincent
Veröffentlicht in: Trials, Ausgabe 3, 2022, ISSN 1745-6215
Herausgeber: BioMed Central
DOI: 10.1186/s13063-022-06431-5

Paravertebral block for the prevention of chronic postsurgical pain after breast cancer surgery

Autoren: Hakim Harkouk, Dominique Fletcher, Valeria Martinez
Veröffentlicht in: Regional Anesthesia & Pain Medicine, Ausgabe 46/3, 2021, Seite(n) 251-257, ISSN 1098-7339
Herausgeber: W. B. Saunders Co., Ltd.
DOI: 10.1136/rapm-2020-102040

Comprehensive quantitative sensory testing shows altered sensory function in women with chronic pelvic pain: results from the Translational Research in Pelvic Pain (TRiPP) Study.

Autoren: Coxon, Lydiaa,*; Vollert, Janb,c,d,e; Perro, Daniellea; Lunde, Claire E.a,f,g; Ferreira-Gomes, Joanah; Charrua, Anah; Abreu-Mendes, Pedroh; Krassowski, Michala; Birch, Judyi; Meijlink, Janej; Hummelshoj, Lonek; Hoffmann, Anjal; Aziz, Qasimm; Arendt-Nielsen, Larsn,o; Pogatzki-Zahn, Estherb; Evans, Emmaa; Demetriou, Lysiaa; McMahon, Stephen B.p; Missmer, Stacey A.q,r,s; Becker, Christian M.a; Zonder
Veröffentlicht in: Pain, 2023, ISSN 0304-3959
Herausgeber: Elsevier BV
DOI: 10.1097/j.pain.0000000000002955

The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models

Autoren: Ana Catarina Neto,Mariana Santos-Pereira,Pedro Abreu-Mendes,Delminda Neves,Henrique Almeida,Francisco Cruz andAna Charrua
Veröffentlicht in: Biomedicines, 2023, ISSN 2227-9059
Herausgeber: MDPI
DOI: 10.3390/biomedicines11030696

Developing consensus on core outcome domains and measurement instruments for assessing effectiveness in perioperative pain management after sternotomy, breast cancer surgery, total knee arthroplasty, and surgery related to endometriosis

Autoren: Ulrike Kaiser, Hiltrud Liedgens, Winfried Meissner, Claudia Weinmann, Peter Zahn, Esther Pogatzki-Zahn
Veröffentlicht in: Trials, Ausgabe 21/1, 2020, ISSN 1745-6215
Herausgeber: BioMed Central
DOI: 10.1186/s13063-020-04665-9

Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans

Autoren: A. Di Lionardo, G. Di Stefano, C. Leone, G. Di Pietro, E. Sgro, E. Malara, C. Cosentino, C. Mollica, A. J. Blockeel, O. Caspani, L. Garcia-Larrea, A. Mouraux, R. D. Treede, K. G. Phillips, M. Valeriani & Andrea Truini
Veröffentlicht in: Scientific reports, 2021, ISSN 2045-2322
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41598-021-00313-7

How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex

Autoren: Leone C, Di Lionardo A, Di Pietro G, Di Stefano G, Falco P, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Phillips KG, Treede RD, Truini A.
Veröffentlicht in: Clin Neurophysiol ., 2021, ISSN 1388-2457
Herausgeber: Elsevier BV
DOI: 10.1016/j.clinph.2021.08.018

Association of sensory phenotype with quality of life, functionality, and emotional well-being in patients suffering from neuropathic pain

Autoren: Gierthmühlen, Jannea,*; Böhmer, Johanna; Attal, Nadineb; Bouhassira, Didierb; Freynhagen, Rainerc,d; Haanpää, Maijae; Hansson, Perf,g; Jensen, Troels Staehelinh; Kennedy, Jeffreyi; Maier, Christophj; Rice, Andrew S.C.k; Sachau, Julianea; Segerdahl, Märtal; Sindrup, Sörenm; Tölle, Thomasn; Treede, Rolf-Detlefo; Ventzel, Lisef,p; Vollert, Jana,o; Baron, Ralfa
Veröffentlicht in: Pain, 2021, ISSN 0304-3959
Herausgeber: Elsevier BV
DOI: 10.1097/j.pain.0000000000002501

Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome

Autoren: Paulina Nunez-Badinez, Bianca De Leo, Alexis Laux-Biehlmann, Anja Hoffmann, Thomas M. Zollner, Philippa T.K. Saunders, Ioannis Simitsidellis, Ana Charrua, Francisco Cruz, Raul Gomez, Miguel Angel Tejada, Stephen B. McMahon, Laure Lo Re, Florent Barthas, Katy Vincent, Judy Birch, Jane Meijlink, Lone Hummelshoj, Patrick J. Sweeney, J. Douglas Armstrong, Rolf-Detlef Treede, Jens Nagel
Veröffentlicht in: Pain, Ausgabe Publish Ahead of Print, 2021, Seite(n) 2021, ISSN 0304-3959
Herausgeber: Elsevier BV
DOI: 10.1097/j.pain.0000000000002248

Patient reported outcome measures in chronic neuropathic pain clinical trials - a systematic literature review.

Autoren: Sachau J, Sendel M, Péchard M, Schnabel K, Schmieg I, Medkour T, Ecochard L, Woischnik M, Liedgens H, Pogatzki-Zahn E, Baron R, Bouhassira D.
Veröffentlicht in: The journal of pain, 2022, ISSN 1526-5900
Herausgeber: Churchill Livingstone
DOI: 10.1016/j.jpain.2022.09.003

Human surrogate models of central sensitization: A critical review and practical guide

Autoren: Charles Quesada, Anna Kostenko, Idy Ho, Caterina Leone, Zahra Nochi, Alexandre Stouffs, Matthias Wittayer, Ombretta Caspani, Nanna Brix Finnerup, André Mouraux, Gisèle Pickering, Irene Tracey, Andrea Truini, Rolf‐Detlef Treede, Luis Garcia‐Larrea
Veröffentlicht in: European Journal of Pain, 2021, ISSN 1090-3801
Herausgeber: W. B. Saunders Co., Ltd.
DOI: 10.1002/ejp.1768

IMI-PAINCARE, BIOPAIN : validation chez l’homme de nouveaux biomarqueurs fonctionnels pour le développement pharmacologique de traitements de la douleur

Autoren: A. Stouffs, L. Lebrun, A. Mouraux
Veröffentlicht in: Douleur et Analgésie, Ausgabe 31/4, 2018, Seite(n) 230-231, ISSN 1011-288X
Herausgeber: Editions Medecine et Hygiene
DOI: 10.3166/dea-2018-0041

Urinary bladder sigma-1 receptors: A new target for cystitis treatment

Autoren: Rafael González-Cano, Antonia Artacho-Cordón, Lucía Romero, Miguel A. Tejada, Francisco R. Nieto, Manuel Merlos, Francisco J. Cañizares, Cruz M. Cendán, Eduardo Fernández-Segura, José M. Baeyens
Veröffentlicht in: Pharmacological Research, Ausgabe 155, 2020, Seite(n) 104724, ISSN 1043-6618
Herausgeber: Academic Press
DOI: 10.1016/j.phrs.2020.104724

Effect of Water Avoidance Stress on serum and urinary NGF levels in rats: diagnostic and therapeutic implications for BPS/IC patients

Autoren: Bruno Dias, Paula Serrão, Francisco Cruz, Ana Charrua
Veröffentlicht in: Scientific Reports, Ausgabe 9/1, 2019, ISSN 2045-2322
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41598-019-50576-4

Rodent Animal Models of Endometriosis-Associated Pain: Unmet Needs and Resources Available for Improving Translational Research in Endometriosis.

Autoren: Tejada, M. A., Antunez, C., Nunez-Badinez, P., De Leo, B., Saunders, P. T., Vincent, K., Cano, A., Nagel, J., & Gomez, R.
Veröffentlicht in: International journal of molecular sciences, 2023, ISSN 1422-0067
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24032422

The N13 spinal component of somatosensory evoked potentials is modulated by heterotopic noxious conditioning stimulation suggesting an involvement of spinal wide dynamic range neurons

Autoren: Pietro GD, Stefano GD, Leone C, Lionardo AD, Sgrò E, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Phillips KG, Treede RD, Valeriani M, Truini A.
Veröffentlicht in: Neurophysiologie Clinique, 2021, ISSN 0987-7053
Herausgeber: Elsevier Masson
DOI: 10.1016/j.neucli.2021.09.001

Clinical profiling of specific diagnostic subgroups of women with chronic pelvic pain.

Autoren: Lysia Demetriou, Michal Krassowski, Pedro Abreu Mendes, Kurtis Garbutt, Allison F. Vitonis, Elizabeth Wilkins, Lydia Coxon, Lars Arendt-Nielsen, Qasim Aziz, Judy Birc, Andrew W. Horne, Anja Hoffman, Lone Hummelshoj, Claire E. Lunde, Jane Meijlink, Danielle Perro, Nilufer Rahmioglu, Kathryn L. Terry, Esther Pogatzki-Zahn, Christine B. Sieberg, Rolf-Detlef Treede, Christian M. Becker, Francisco Cruz
Veröffentlicht in: Frontiers in Reproductive Health, 2023, ISSN 2673-3153
Herausgeber: Lausanne Frontiers Media SA [2020]-
DOI: 10.3389/frph.2023.1140857

INTEGRATE-Pain: a transatlantic consortium to advance development of effective pain management

Autoren: Laura D Wandner, PhD, Petra Bloms-Funke, PhD, Giulia Bova, MA, Anthony Domenichiello, PhD, Anja Hoffmann, MD, Smriti Iyengar, PhD, Barbara I Karp, MD, Janelle Letzen, PhD, Hiltrud Liedgens, PhD, Durga P Mohapatra, PhD, Jens Nagel, PhD, Mary Ann Pelleymounter, PhD, Esther Pogatzki-Zahn, MD, Leah Pogorzala, PhD, Jan Vollert, PhD, Sarah A Woller, PhD, Rolf-Detlef Treede, MD
Veröffentlicht in: Pain Medicine, 2023, ISSN 1526-4637
Herausgeber: American Academy of Pain Medicine
DOI: 10.1093/pm/pnad033

Developing consensus on core outcome domains for assessing effectiveness in perioperative pain management

Autoren: Esther M. Pogatzki-Zahn, Hiltrud Liedgens, Lone Hummelshoj, Winfried Meissner, Claudia Weinmann, Rolf-Detlef Treede, Katy Vincent, Peter Zahn, Ulrike Kaiser
Veröffentlicht in: Pain, Ausgabe Publish Ahead of Print, 2021, Seite(n) 2021, ISSN 0304-3959
Herausgeber: Elsevier BV
DOI: 10.1097/j.pain.0000000000002254

IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG)

Autoren: André Mouraux, Petra Bloms-Funke, Irmgard Boesl, Ombretta Caspani, Sonya C. Chapman, Giulia Di Stefano, Nanna Brix Finnerup, Luis Garcia-Larrea, Marcus Goetz, Anna Kostenko, Bernhard Pelz, Esther Pogatzki-Zahn, Karin Schubart, Alexandre Stouffs, Andrea Truini, Irene Tracey, Iñaki F. Troconiz, Johannes Van Niel, Jose Miguel Vela, Katy Vincent, Jan Vollert, Vishvarani Wanigasekera, Matthias Wittay
Veröffentlicht in: Trials, Ausgabe 22/1, 2021, ISSN 1745-6215
Herausgeber: BioMed Central
DOI: 10.1186/s13063-021-05272-y

The test-retest reliability of large and small fiber nerve excitability testing with threshold tracking.

Autoren: Pia H, Nochi Z, Kristensen AG, Pelz B, Goetz M, Hoeink JN, Blockeel AJ, Mouraux A, Truini A, Finnerup NB, Phillips KG, Treede RD, Tankisi H.
Veröffentlicht in: Clinical neurophysiology practice, 2023, ISSN 2467-981X
Herausgeber: Elsevier B.V.
DOI: 10.1016/j.cnp.2023.03.003

Pharmacological Probes to Validate Biomarkers for Analgesic Drug Development.

Autoren: van Niel J, Bloms-Funke P, Caspani O, Cendros JM, Garcia-Larrea L, Truini A, Tracey I, Chapman SC, Marco-Ariño N, Troconiz IF, Phillips K, Finnerup NB, Mouraux A, Treede R-D
Veröffentlicht in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23158295

Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain.

Autoren: Tejada MA, Santos-Llamas AI, Escriva L, Tarin JJ, Cano A, Fernández-Ramírez MJ, Nunez-Badinez P, De Leo B, Saunders PTK, Vidal V, Barthas F, Vincent K, Sweeney PJ, Sillito RR, Armstrong JD, Nagel J, Gomez R.
Veröffentlicht in: Biomedicines, 2022, ISSN 2227-9059
Herausgeber: MDPI
DOI: 10.3390/biomedicines10020501

IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET).

Autoren: Nochi Z, Pia H, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Fardo F, Genser B, Goetz M, Kostenko AV, Leone C, Li T, Mouraux A, Pelz B, Pogatzki-Zahn E, Schilder A, Schnetter E, Schubart K, Stouffs A, Tracey I, Troconiz IF, Truini A, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Tankisi H, Finnerup NB, Phillips KG, Treede RD.
Veröffentlicht in: Trials, 2022, ISSN 1745-6215
Herausgeber: BioMed Central
DOI: 10.1186/s13063-022-06087-1

Pre-clinical models of endometriosis and their value for translational research.

Autoren: P. Nunez-Badinez
Veröffentlicht in: Drug Target Review, 2022
Herausgeber: Russell Publishing Ltd.

New approach in research on two pelvic pain disorders

Autoren: Paulina Nunez-Badinez, Judy Birch, Lydia Coxon
Veröffentlicht in: 2020
Herausgeber: Mediaplanet

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