Improving the care of patients suffering from acute or chronic pain

Informazioni relative al progetto

IMI-PainCare

ID dell’accordo di sovvenzione: 777500

DOI

10.3030/777500

Progetto chiuso

Data della firma CE 4 Maggio 2018

Data di avvio 1 Aprile 2018

Data di completamento 31 Marzo 2023

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 23 405 673,12

Contributo UE

€ 11 225 271,25

Coordinato da

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (14)

Review of clinical and preclinical literature on biomarkers and medication

INSERM-B/GRT

Study design proposal for using validated biomarkers in clinical trials in patients

Consensus on final trial designs for BioPainRCT1, BioPainRCT2, BioPainRCT3 and BioPainRCT4

UHEI/GRT

Report on the INTEGRATE-Pain Consortium Meeting in Aug 2020

Report on the virtual INTEGRATEPain meeting in August 2020 together with the NIHHEAL initiative

White Book publication/submission

LEAD UHEI GRT

Characterization of the standardized PROMs for chronic pain, mirroring pain state as well as cognitive and functional consequences for use in clinical practice and communication by the expert panel

LEAD CAU INSERMP

Report on status of posting WP2 results (PROMPT-NIT1)

PROMs consensus for use in clinical practice / hospitals, and in RCTs, for post-operative pain

LEAD WWW GRT

EMA guidance document submitted

Translational evaluation of biomarker response in different compartments of the nociceptive system at clinically effective concentrations

LEAD UHEIUNAV

Visualization of results of PROM-NIT1 for feedback to participating hospitals

Complete set up of all primary biomarkers

Study synopsis and protocol uploaded to EudraCT

AU, GRT

Publication of test-retest reliability and site-to-site reproducibility of biomarker results

LEAD UHEI LIL

Other (1)

Website and social media account set-up

Pubblicazioni

Peer reviewed articles (24)

IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the efects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity

Autori: Leone, Caterina Maria; Di Stefano, Giulia; Di Pietro, Giuseppe; Bloms-Funke, Petra; Boesls, Irmgrad; Caspani, Ombretta; Chapman, Sonya C; Finnerup, Nanna Brix; Garcia-Larrea, Luis; Li, Tom; Goetz, Marcus; Mouraux, André; Pelz, Bernhard; Pogatzki-Zahn,Esther; Schilder, Andreas; Schnetter, Erik; Schubart, Karin; Tracey, Irene; Troconiz, Inaki F; Van Niel, Hans; Vela Hernandez, Josè Miguel; Vincent
Pubblicato in: Trials, Numero 3, 2022, ISSN 1745-6215
Editore: BioMed Central
DOI: 10.1186/s13063-022-06431-5

Paravertebral block for the prevention of chronic postsurgical pain after breast cancer surgery

Autori: Hakim Harkouk, Dominique Fletcher, Valeria Martinez
Pubblicato in: Regional Anesthesia & Pain Medicine, Numero 46/3, 2021, Pagina/e 251-257, ISSN 1098-7339
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1136/rapm-2020-102040

Comprehensive quantitative sensory testing shows altered sensory function in women with chronic pelvic pain: results from the Translational Research in Pelvic Pain (TRiPP) Study.

Autori: Coxon, Lydiaa,*; Vollert, Janb,c,d,e; Perro, Daniellea; Lunde, Claire E.a,f,g; Ferreira-Gomes, Joanah; Charrua, Anah; Abreu-Mendes, Pedroh; Krassowski, Michala; Birch, Judyi; Meijlink, Janej; Hummelshoj, Lonek; Hoffmann, Anjal; Aziz, Qasimm; Arendt-Nielsen, Larsn,o; Pogatzki-Zahn, Estherb; Evans, Emmaa; Demetriou, Lysiaa; McMahon, Stephen B.p; Missmer, Stacey A.q,r,s; Becker, Christian M.a; Zonder
Pubblicato in: Pain, 2023, ISSN 0304-3959
Editore: Elsevier BV
DOI: 10.1097/j.pain.0000000000002955

The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models

Autori: Ana Catarina Neto,Mariana Santos-Pereira,Pedro Abreu-Mendes,Delminda Neves,Henrique Almeida,Francisco Cruz andAna Charrua
Pubblicato in: Biomedicines, 2023, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines11030696

Developing consensus on core outcome domains and measurement instruments for assessing effectiveness in perioperative pain management after sternotomy, breast cancer surgery, total knee arthroplasty, and surgery related to endometriosis

Autori: Ulrike Kaiser, Hiltrud Liedgens, Winfried Meissner, Claudia Weinmann, Peter Zahn, Esther Pogatzki-Zahn
Pubblicato in: Trials, Numero 21/1, 2020, ISSN 1745-6215
Editore: BioMed Central
DOI: 10.1186/s13063-020-04665-9

Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans

Autori: A. Di Lionardo, G. Di Stefano, C. Leone, G. Di Pietro, E. Sgro, E. Malara, C. Cosentino, C. Mollica, A. J. Blockeel, O. Caspani, L. Garcia-Larrea, A. Mouraux, R. D. Treede, K. G. Phillips, M. Valeriani & Andrea Truini
Pubblicato in: Scientific reports, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-00313-7

How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex

Autori: Leone C, Di Lionardo A, Di Pietro G, Di Stefano G, Falco P, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Phillips KG, Treede RD, Truini A.
Pubblicato in: Clin Neurophysiol ., 2021, ISSN 1388-2457
Editore: Elsevier BV
DOI: 10.1016/j.clinph.2021.08.018

Association of sensory phenotype with quality of life, functionality, and emotional well-being in patients suffering from neuropathic pain

Autori: Gierthmühlen, Jannea,*; Böhmer, Johanna; Attal, Nadineb; Bouhassira, Didierb; Freynhagen, Rainerc,d; Haanpää, Maijae; Hansson, Perf,g; Jensen, Troels Staehelinh; Kennedy, Jeffreyi; Maier, Christophj; Rice, Andrew S.C.k; Sachau, Julianea; Segerdahl, Märtal; Sindrup, Sörenm; Tölle, Thomasn; Treede, Rolf-Detlefo; Ventzel, Lisef,p; Vollert, Jana,o; Baron, Ralfa
Pubblicato in: Pain, 2021, ISSN 0304-3959
Editore: Elsevier BV
DOI: 10.1097/j.pain.0000000000002501

Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome

Autori: Paulina Nunez-Badinez, Bianca De Leo, Alexis Laux-Biehlmann, Anja Hoffmann, Thomas M. Zollner, Philippa T.K. Saunders, Ioannis Simitsidellis, Ana Charrua, Francisco Cruz, Raul Gomez, Miguel Angel Tejada, Stephen B. McMahon, Laure Lo Re, Florent Barthas, Katy Vincent, Judy Birch, Jane Meijlink, Lone Hummelshoj, Patrick J. Sweeney, J. Douglas Armstrong, Rolf-Detlef Treede, Jens Nagel
Pubblicato in: Pain, Numero Publish Ahead of Print, 2021, Pagina/e 2021, ISSN 0304-3959
Editore: Elsevier BV
DOI: 10.1097/j.pain.0000000000002248

Patient reported outcome measures in chronic neuropathic pain clinical trials - a systematic literature review.

Autori: Sachau J, Sendel M, Péchard M, Schnabel K, Schmieg I, Medkour T, Ecochard L, Woischnik M, Liedgens H, Pogatzki-Zahn E, Baron R, Bouhassira D.
Pubblicato in: The journal of pain, 2022, ISSN 1526-5900
Editore: Churchill Livingstone
DOI: 10.1016/j.jpain.2022.09.003

Human surrogate models of central sensitization: A critical review and practical guide

Autori: Charles Quesada, Anna Kostenko, Idy Ho, Caterina Leone, Zahra Nochi, Alexandre Stouffs, Matthias Wittayer, Ombretta Caspani, Nanna Brix Finnerup, André Mouraux, Gisèle Pickering, Irene Tracey, Andrea Truini, Rolf‐Detlef Treede, Luis Garcia‐Larrea
Pubblicato in: European Journal of Pain, 2021, ISSN 1090-3801
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1002/ejp.1768

IMI-PAINCARE, BIOPAIN : validation chez l’homme de nouveaux biomarqueurs fonctionnels pour le développement pharmacologique de traitements de la douleur

Autori: A. Stouffs, L. Lebrun, A. Mouraux
Pubblicato in: Douleur et Analgésie, Numero 31/4, 2018, Pagina/e 230-231, ISSN 1011-288X
Editore: Editions Medecine et Hygiene
DOI: 10.3166/dea-2018-0041

Urinary bladder sigma-1 receptors: A new target for cystitis treatment

Autori: Rafael González-Cano, Antonia Artacho-Cordón, Lucía Romero, Miguel A. Tejada, Francisco R. Nieto, Manuel Merlos, Francisco J. Cañizares, Cruz M. Cendán, Eduardo Fernández-Segura, José M. Baeyens
Pubblicato in: Pharmacological Research, Numero 155, 2020, Pagina/e 104724, ISSN 1043-6618
Editore: Academic Press
DOI: 10.1016/j.phrs.2020.104724

Effect of Water Avoidance Stress on serum and urinary NGF levels in rats: diagnostic and therapeutic implications for BPS/IC patients

Autori: Bruno Dias, Paula Serrão, Francisco Cruz, Ana Charrua
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-50576-4

Rodent Animal Models of Endometriosis-Associated Pain: Unmet Needs and Resources Available for Improving Translational Research in Endometriosis.

Autori: Tejada, M. A., Antunez, C., Nunez-Badinez, P., De Leo, B., Saunders, P. T., Vincent, K., Cano, A., Nagel, J., & Gomez, R.
Pubblicato in: International journal of molecular sciences, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24032422

The N13 spinal component of somatosensory evoked potentials is modulated by heterotopic noxious conditioning stimulation suggesting an involvement of spinal wide dynamic range neurons

Autori: Pietro GD, Stefano GD, Leone C, Lionardo AD, Sgrò E, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Phillips KG, Treede RD, Valeriani M, Truini A.
Pubblicato in: Neurophysiologie Clinique, 2021, ISSN 0987-7053
Editore: Elsevier Masson
DOI: 10.1016/j.neucli.2021.09.001

Clinical profiling of specific diagnostic subgroups of women with chronic pelvic pain.

Autori: Lysia Demetriou, Michal Krassowski, Pedro Abreu Mendes, Kurtis Garbutt, Allison F. Vitonis, Elizabeth Wilkins, Lydia Coxon, Lars Arendt-Nielsen, Qasim Aziz, Judy Birc, Andrew W. Horne, Anja Hoffman, Lone Hummelshoj, Claire E. Lunde, Jane Meijlink, Danielle Perro, Nilufer Rahmioglu, Kathryn L. Terry, Esther Pogatzki-Zahn, Christine B. Sieberg, Rolf-Detlef Treede, Christian M. Becker, Francisco Cruz
Pubblicato in: Frontiers in Reproductive Health, 2023, ISSN 2673-3153
Editore: Lausanne Frontiers Media SA [2020]-
DOI: 10.3389/frph.2023.1140857

INTEGRATE-Pain: a transatlantic consortium to advance development of effective pain management

Autori: Laura D Wandner, PhD, Petra Bloms-Funke, PhD, Giulia Bova, MA, Anthony Domenichiello, PhD, Anja Hoffmann, MD, Smriti Iyengar, PhD, Barbara I Karp, MD, Janelle Letzen, PhD, Hiltrud Liedgens, PhD, Durga P Mohapatra, PhD, Jens Nagel, PhD, Mary Ann Pelleymounter, PhD, Esther Pogatzki-Zahn, MD, Leah Pogorzala, PhD, Jan Vollert, PhD, Sarah A Woller, PhD, Rolf-Detlef Treede, MD
Pubblicato in: Pain Medicine, 2023, ISSN 1526-4637
Editore: American Academy of Pain Medicine
DOI: 10.1093/pm/pnad033

Developing consensus on core outcome domains for assessing effectiveness in perioperative pain management

Autori: Esther M. Pogatzki-Zahn, Hiltrud Liedgens, Lone Hummelshoj, Winfried Meissner, Claudia Weinmann, Rolf-Detlef Treede, Katy Vincent, Peter Zahn, Ulrike Kaiser
Pubblicato in: Pain, Numero Publish Ahead of Print, 2021, Pagina/e 2021, ISSN 0304-3959
Editore: Elsevier BV
DOI: 10.1097/j.pain.0000000000002254

IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG)

Autori: André Mouraux, Petra Bloms-Funke, Irmgard Boesl, Ombretta Caspani, Sonya C. Chapman, Giulia Di Stefano, Nanna Brix Finnerup, Luis Garcia-Larrea, Marcus Goetz, Anna Kostenko, Bernhard Pelz, Esther Pogatzki-Zahn, Karin Schubart, Alexandre Stouffs, Andrea Truini, Irene Tracey, Iñaki F. Troconiz, Johannes Van Niel, Jose Miguel Vela, Katy Vincent, Jan Vollert, Vishvarani Wanigasekera, Matthias Wittay
Pubblicato in: Trials, Numero 22/1, 2021, ISSN 1745-6215
Editore: BioMed Central
DOI: 10.1186/s13063-021-05272-y

The test-retest reliability of large and small fiber nerve excitability testing with threshold tracking.

Autori: Pia H, Nochi Z, Kristensen AG, Pelz B, Goetz M, Hoeink JN, Blockeel AJ, Mouraux A, Truini A, Finnerup NB, Phillips KG, Treede RD, Tankisi H.
Pubblicato in: Clinical neurophysiology practice, 2023, ISSN 2467-981X
Editore: Elsevier B.V.
DOI: 10.1016/j.cnp.2023.03.003

Pharmacological Probes to Validate Biomarkers for Analgesic Drug Development.

Autori: van Niel J, Bloms-Funke P, Caspani O, Cendros JM, Garcia-Larrea L, Truini A, Tracey I, Chapman SC, Marco-Ariño N, Troconiz IF, Phillips K, Finnerup NB, Mouraux A, Treede R-D
Pubblicato in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23158295

Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain.

Autori: Tejada MA, Santos-Llamas AI, Escriva L, Tarin JJ, Cano A, Fernández-Ramírez MJ, Nunez-Badinez P, De Leo B, Saunders PTK, Vidal V, Barthas F, Vincent K, Sweeney PJ, Sillito RR, Armstrong JD, Nagel J, Gomez R.
Pubblicato in: Biomedicines, 2022, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines10020501

IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET).

Autori: Nochi Z, Pia H, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Fardo F, Genser B, Goetz M, Kostenko AV, Leone C, Li T, Mouraux A, Pelz B, Pogatzki-Zahn E, Schilder A, Schnetter E, Schubart K, Stouffs A, Tracey I, Troconiz IF, Truini A, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Tankisi H, Finnerup NB, Phillips KG, Treede RD.
Pubblicato in: Trials, 2022, ISSN 1745-6215
Editore: BioMed Central
DOI: 10.1186/s13063-022-06087-1

Other (2)

Pre-clinical models of endometriosis and their value for translational research.

Autori: P. Nunez-Badinez
Pubblicato in: Drug Target Review, 2022
Editore: Russell Publishing Ltd.

New approach in research on two pelvic pain disorders

Autori: Paulina Nunez-Badinez, Judy Birch, Lydia Coxon
Pubblicato in: 2020
Editore: Mediaplanet