Novel precision technological platforms to promote non-invasive early diagnosis, eradication and prevention of cancer relapse: proof of concept in the bladder carcinoma.

Deliverables

Websites, patent fillings, videos etc. (3)

At least 5 conferences and at least 3 peer-reviewed papers

At least 5 conferences and at least 3 peer-reviewed papers

Second plan for dissemination and exploitation for ( PUDF)

Second plan for dissemination and exploitation for ( PUDF)

Project website and logo

Project website and logo

Documents, reports (1)

First plan for dissemination and exploitation (using and disseminating the foreground (=PUDF))

First plan for dissemination and exploitation (using and disseminating the foreground (=PUDF))

Publications

Peer reviewed articles (16)

Causal contributors to tissue stiffness and clinical relevance in urology

Author(s): Laura Martinez-Vidal, Valentina Murdica, Chiara Venegoni, Filippo Pederzoli, Marco Bandini, Andrea Necchi, Andrea Salonia, Massimo Alfano
Published in: Communications Biology, 4/1, 2021, Page(s) 1-16, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-021-02539-7

Cardiac remodeling secondary to chronic volume overload is attenuated by a novel MMP9/2 blocking antibody

Author(s): Lena Cohen, Irit Sagi, Einat Bigelman, Inna Solomonov, Anna Aloshin, Jeremy Ben-Shoshan, Zach Rozenbaum, Gad Keren, Michal Entin-Meer
Published in: PLOS ONE, 15/4, 2020, Page(s) e0231202, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0231202

An Application of Multivariate Data Analysis to Photoacoustic Imaging for the Spectral Unmixing of Gold Nanorods in Biological Tissues

Author(s): Mirko Maturi, Paolo Armanetti, Luca Menichetti, Mauro Comes Franchini
Published in: Nanomaterials, 11/1, 2021, Page(s) 142, ISSN 2079-4991
Publisher: RSC (Royal Chemical Society)
DOI: 10.3390/nano11010142

Adhesion force spectroscopy with nanostructured colloidal probes reveals nanotopography-dependent early mechanotransductive interactions at the cell membrane level

Author(s): M. Chighizola, A. Previdi, T. Dini, C. Piazzoni, C. Lenardi, P. Milani, C. Schulte, A. Podestà
Published in: Nanoscale, 12/27, 2020, Page(s) 14708-14723, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr01991g

Distinct extracellular–matrix remodeling events precede symptoms of inflammation

Author(s): Elee Shimshoni, Idan Adir, Ran Afik, Inna Solomonov, Anjana Shenoy, Miri Adler, Luca Puricelli, Fabio Sabino, Simonas Savickas, Odelia Mouhadeb, Nathan Gluck, Sigal Fishman, Lael Werner, Tomer-Meir Salame, Dror S. Shouval, Chen Varol, Ulrich auf dem Keller, Alessandro Podestà, Tamar Geiger, Paolo Milani, Uri Alon, Irit Sagi
Published in: Matrix Biology, 96, 2021, Page(s) 47-68, ISSN 0945-053X
Publisher: Elsevier BV
DOI: 10.1016/j.matbio.2020.11.001

Matrix Metalloproteinases Expression Is Associated with SARS-CoV-2-Induced Lung Pathology and Extracellular-Matrix Remodeling in K18-hACE2 Mice

Author(s): Gutman H, Aftalion M , Melamed S, Politi B, Nevo R, Havusha-Laufer S, Achdout H, Gur D, Israely T, Dachir S, Mamroud E, Sagi I, Vagima Y
Published in: Viruses, 14(8),, 2022, Page(s) 1627, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14081627

Stiffening of DU145 prostate cancer cells driven by actin filaments – microtubule crosstalk conferring resistance to microtubule-targeting drugs

Author(s): Andrzej Kubiak, Matteo Chighizola, Carsten Schulte, Natalia Bryniarska, Julita Wesołowska, Maciej Pudełek, Małgorzata Lasota, Damian Ryszawy, Agnieszka Basta-Kaim, Piotr Laidler, Alessandro Podestà, Małgorzata Lekka
Published in: Nanoscale, 13/12, 2021, Page(s) 6212-6226, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr06464e

Mechanotransduction in neuronal cell development and functioning

Author(s): Matteo Chighizola, Tania Dini, Cristina Lenardi, Paolo Milani, Alessandro Podestà, Carsten Schulte
Published in: Biophysical Reviews, 11/5, 2019, Page(s) 701-720, ISSN 1867-2450
Publisher: Springer Verlag
DOI: 10.1007/s12551-019-00587-2

Current concepts in nanostructured contrast media development for in vivo photoacoustic imaging

Author(s): Mirko Maturi, Erica Locatelli, Ilaria Monaco, Mauro Comes Franchini
Published in: Biomaterials Science, 7/5, 2019, Page(s) 1746-1775, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8bm01444b

Exosomes as a storehouse of tissue remodeling proteases and mediators of cancer progression

Author(s): Alakesh Das, Vishnu Mohan, Venkat Raghavan Krishnaswamy, Inna Solomonov, Irit Sagi
Published in: Cancer and Metastasis Reviews, 2019, Page(s) 455–468, ISSN 0072-7830
Publisher: springer science & business media
DOI: 10.1007/s10555-019-09813-5

A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8

Author(s): Francesca Nardelli, Michela Ghitti, Giacomo Quilici, Alessandro Gori, Qingqiong Luo, Andrea Berardi, Angelina Sacchi, Matteo Monieri, Greta Bergamaschi, Wolfgang Bermel, Fuxiang Chen, Angelo Corti, Flavio Curnis, Giovanna Musco
Published in: Chemical Communications, 2019, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9cc08518a

MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy

Author(s): Mark Owyong, Jonathan Chou, Renske JE van den Bijgaart, Niwen Kong, Gizem Efe, Carrie Maynard, Dalit Talmi-Frank, Inna Solomonov, Charlotte Koopman, Elin Hadler-Olsen, Mark Headley, Charlene Lin, Chih-Yang Wang, Irit Sagi, Zena Werb, Vicki Plaks
Published in: Life Science Alliance, 2/6, 2019, Page(s) e201800226, ISSN 2575-1077
Publisher: Cold Spring Harbor Laboratory
DOI: 10.26508/lsa.201800226

LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis

Author(s): Mordehay Klepfish, Tamar Gross, Milena Vugman, Nikolaos A. Afratis, Sapir Havusha-Laufer, Eli Brazowski, Inna Solomonov, Chen Varol, Irit Sagi
Published in: Frontiers in Immunology, 11, 2020, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.00480

Influence of natural convection on gold nanorods-assisted photothermal treatment of bladder cancer in mice

Author(s): Ean H. Ooi, Viktor Popov, Massimo Alfano, Jason K. K. Cheong
Published in: International Journal of Hyperthermia, 37/1, 2020, Page(s) 634-650, ISSN 0265-6736
Publisher: Taylor & Francis
DOI: 10.1080/02656736.2020.1771437

Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts

Author(s): Kwanghee Kim, Wenhuo Hu, François Audenet, Nima Almassi, Aphrothiti J. Hanrahan, Katie Murray, Aditya Bagrodia, Nathan Wong, Timothy N. Clinton, Shawn Dason, Vishnu Mohan, Sylvia Jebiwott, Karan Nagar, Jianjiong Gao, Alex Penson, Chris Hughes, Benjamin Gordon, Ziyu Chen, Yiyu Dong, Philip A. Watson, Ricardo Alvim, Arijh Elzein, Sizhi P. Gao, Emiliano Cocco, Alessandro D. Santin, Irina Ostrovnaya,
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15885-7

A numerical study to investigate the effects of tumour position on the treatment of bladder cancer in mice using gold nanorods assisted photothermal ablation.

Author(s): Jason K. K. Cheong; Viktor Popov; Elisa Alchera; Irene Locatelli; Massimo Alfano; Luca Menichetti; Paolo Armanetti; Mirko Maturi; Mauro Comes Franchini; Ean H. Ooi; Yeong Shiong Chiew
Published in: Computers in Biology and Medicine, 1, 2021, ISSN 0346-251X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.104881

Monographic books (2)

Multi-well Fibrillation Assay as a Tool for Analyzing Crosslinking and Stabilization of Collagen,

Author(s): V.R. Krishnaswamy
Published in: COLLAGEN Methods and protocols, 2019, ISBN 1493990942
Publisher: Springer

Sample Preparation of Extracellular Matrix of Murine

Author(s): E. Shimshoni, I Sagi
Published in: COLLAGEN Methods and protocols, 1, 2019
Publisher: Springer