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directed EVOlution in DROPS

Objective

Natural evolution is a powerful process that has given rise to the functionally diverse set of proteins present in all living systems. Repetitive rounds of mutation, selection and amplification have optimised nature’s catalysts, the enzymes, to perform an enormous range of different reactions. However, natural evolution has driven the optimisation of enzymes subjected to living functions of microorganisms, according to ill-defined and fluctuating external conditions and is not suitable
for industrial processes since it lacks of control of selection pressure. In EVOdrops, we will use directed evolution to overcome these limitations. It is a synthetic, man-made approach of evolution, aiming at improving living systems based on predefined needs, controlling the external selection pressure. While natural evolution took billions of years to optimise
macromolecules, directed evolution – to be efficient in an industrial process – requires both the generation of genetic diversity and ultra-high throughput screening capabilities to recover the variants of interest. We will develop and optimise these tools using the ground-breaking potential of droplet-based microfluidics for high-throughput experimentation and the
fine control of gene library construction. EVOdrops, a European training network, will bring together the leading research scientists, laboratories and industries in Europe with outstanding expertise in protein engineering and microfluidics and 13 early stage researchers. We will offer an extensive multi- and interdisciplinary training to ensure that they can solve these urgent and unmet challenges in biotechnology and biomedicine. We will use a multidisciplinary approach combining soft matter, microfluidics and chemical biology to design solutions for the selection of new enzymes of industrial and therapeutic interest. In the future, our approaches can be generalised to challenges involving high-throughput miniaturised biochemical or cell-based assays.
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Coordinator

UNIVERSITY OF GLASGOW

Address

University Avenue
G12 8qq Glasgow

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 606 345,12

Participants (10)

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 527 543,58

VILNIAUS UNIVERSITETAS

Lithuania

EU Contribution

€ 223 947

TECHNISCHE UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 252 788,40

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

EU Contribution

€ 281 276,64

INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK

Poland

EU Contribution

€ 227 478,60

UNIVERSITE CATHOLIQUE DE LOUVAIN

Belgium

EU Contribution

€ 256 320

UNIVERSITE PARIS DESCARTES

France

EU Contribution

€ 274 802,04

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 303 172,56

BIOMILLENIA

France

EU Contribution

€ 274 802,04

UAB THERMO FISHER SCIENTIFIC BALTICS

Lithuania

EU Contribution

€ 223 947

Partners (8)

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SPHERE FLUIDICS LIMITED

BLACKTRACE HOLDINGS LIMITED

DROP-TECH LTD

MICROFLUIDIC CHIPSHOP GMBH

BASF SE

THE UNIVERSITY OF HONG KONG

ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS

PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Project information

Grant agreement ID: 813786

Status

Ongoing project

  • Start date

    1 October 2018

  • End date

    30 September 2022

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 452 422,98

  • EU contribution

    € 3 452 422,98

Coordinated by:

UNIVERSITY OF GLASGOW

United Kingdom