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directed EVOlution in DROPS

Objective

Natural evolution is a powerful process that has given rise to the functionally diverse set of proteins present in all living systems. Repetitive rounds of mutation, selection and amplification have optimised nature’s catalysts, the enzymes, to perform an enormous range of different reactions. However, natural evolution has driven the optimisation of enzymes subjected to living functions of microorganisms, according to ill-defined and fluctuating external conditions and is not suitable
for industrial processes since it lacks of control of selection pressure. In EVOdrops, we will use directed evolution to overcome these limitations. It is a synthetic, man-made approach of evolution, aiming at improving living systems based on predefined needs, controlling the external selection pressure. While natural evolution took billions of years to optimise
macromolecules, directed evolution – to be efficient in an industrial process – requires both the generation of genetic diversity and ultra-high throughput screening capabilities to recover the variants of interest. We will develop and optimise these tools using the ground-breaking potential of droplet-based microfluidics for high-throughput experimentation and the
fine control of gene library construction. EVOdrops, a European training network, will bring together the leading research scientists, laboratories and industries in Europe with outstanding expertise in protein engineering and microfluidics and 13 early stage researchers. We will offer an extensive multi- and interdisciplinary training to ensure that they can solve these urgent and unmet challenges in biotechnology and biomedicine. We will use a multidisciplinary approach combining soft matter, microfluidics and chemical biology to design solutions for the selection of new enzymes of industrial and therapeutic interest. In the future, our approaches can be generalised to challenges involving high-throughput miniaturised biochemical or cell-based assays.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/mutation
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

H2020-MSCA-ITN-2018
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITY OF GLASGOW
Address
University Avenue
G12 8QQ Glasgow
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 606 345,12

Participants (11)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 527 543,58
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
VILNIAUS UNIVERSITETAS
Lithuania
EU contribution
€ 223 947
Address
Universiteto G. 3
01513 Vilnius
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 252 788,40
Address
Arcisstrasse 21
80333 Muenchen
Activity type
Higher or Secondary Education Establishments
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 281 276,64
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
INSTYTUT CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK
Poland
EU contribution
€ 227 478,60
Address
Kasprzaka 44/52
01224 Warszawa
Activity type
Higher or Secondary Education Establishments
UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
EU contribution
€ 256 320
Address
Place De L Universite 1
1348 Louvain La Neuve
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE PARIS
France
EU contribution
€ 274 802,04
Address
85 Bd Saint Germain
75006 Paris
Activity type
Higher or Secondary Education Establishments
UNIVERSITE PARIS DESCARTES

Participation ended

France
EU contribution
€ 0
Address
Rue De L Ecole De Medecine 12
75270 Paris Cedex 06
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 303 172,56
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
BIOMILLENIA
France
EU contribution
€ 274 802,04
Address
102 Avenue Gaston Roussel Biocitech
93230 Romainville
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UAB THERMO FISHER SCIENTIFIC BALTICS
Lithuania
EU contribution
€ 223 947
Address
V.graiciuno 8
02241 Vilnius
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (8)

SPHERE FLUIDICS LIMITED
United Kingdom
Address
The Jonas Webb Building, Babraham Research Campus
CB22 3AT Babraham Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BLACKTRACE HOLDINGS LIMITED
United Kingdom
Address
Jarman Way 27
SG8 5HW Royston
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DROP-TECH LTD
United Kingdom
Address
Canterbury Street, Canterbury Court 91
CB4 3QU Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MICROFLUIDIC CHIPSHOP GMBH
Germany
Address
Stockholmer Strasse 20
07747 Jena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BASF SE
Germany
Address
Carl Bosch Strasse 38
67063 Ludwigshafen Am Rhein
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE UNIVERSITY OF HONG KONG
Hong Kong
Address
Pokfulam Road
Pokfulam
Activity type
Higher or Secondary Education Establishments
ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS
France
Address
Rue Vauquelin 10
75231 Paris
Activity type
Higher or Secondary Education Establishments
PRESIDENT AND FELLOWS OF HARVARD COLLEGE
United States
Address
Massachusetts Avenue 1350
02138 Cambridge
Activity type
Higher or Secondary Education Establishments