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Hemoglobin based Protein Nanocarriers for Tumour Oxygenation and a more effective Photodynamic Therapy

Objective

A major drawback of Photodynamic Therapy (PDT) and other therapies for cancer treatment is the limited oxygen content, hypoxia, in tumour tissue. In PDT a photosensitizing molecule is delivered to malignant tissue to generate radical oxygen species (ROS). The presence of oxygen is fundamental for ROS generation, ultimately causing the death of tumour cells.
This project aims to develop hemoglobin drug delivery nanocarriers in the nano and submicron range for simultaneous oxygen and photosensitizer delivery to tumour tissue for a more efficient Photodynamic Therapy.
Hemoglobin-based nanocarriers (HOBCs) will be prepared by co-precipitation of hemoglobin with carbonates and surface coating with bovine serum albumin. The carriers will transport oxygen complexed to hemoglobin while photosensitizer molecules will be entrapped in the core. Carriers will be modified with homing peptides to target them to cancer cells. In vitro studies will be conducted to study the uptake of HOBCs by cells, their intracellular fate, toxicity, and oxygen and photosensitizer delivery. In vivo fate of carriers will be studied in mice with radiolabeled carriers by Positron Emission Tomography and Single Emission Computer Tomography. The efficiency of the HOBCs for oxygen delivery and for PDT will be tested in vitro and in vivo in breast and skin cancer models.
A multidisciplinary team has been gathered with scientists at the forefront of Material Science, Self assembly, Physics, Chemistry, Imaging, Molecular Biology and Cancer Therapy from Germany, Estonia, Spain, Brazil, Argentina and Thailand. The participation of a SME will be fundamental for the future commercialization of project developments. OXIGENATED will actively work towards exchanging skills and knowledge through secondments of Early Stage and Experienced Researchers, and through networking and training activities. Seconded researchers will develop new scientific and complementary skills while exposed to new research environments.

Field of science

  • /engineering and technology/materials engineering/coating and films
  • /natural sciences/biological sciences/molecular biology
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/skin cancer

Call for proposal

H2020-MSCA-RISE-2018
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
Address
Paseo Miramon 182, Parque Tecnologico De San Sebastian Edificio Empresarial C
20009 San Sebastian
Spain
Activity type
Research Organisations
EU contribution
€ 529 000

Participants (3)

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 211 600
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
TARTU ULIKOOL
Estonia
EU contribution
€ 156 400
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
Surflay Nanotec GmbH
Germany
EU contribution
€ 23 000
Address
Max Planck Strasse 3
12489 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (4)

FUNDACAO UNIVERSIDADE DE BRASILIA
Brazil
Address
Campus Universitario Darcy Ribeiro Faculdade De Tecnologie At 05 Bairro Asa Norte
70919 970 Brasilia Df
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN
Argentina
Address
Martin De Irigoyen 3100
1650 San Martin Buenos Aires
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD NACIONAL DEL SUR
Argentina
Address
Avenida Colon 80
8000 Bahia Blanca
Activity type
Higher or Secondary Education Establishments
CHULALONGKORN UNIVERSITY
Thailand
Address
Phyathai Road 254 Pathumwan
10330 Bangkok
Activity type
Higher or Secondary Education Establishments