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Holistic solution to improve animal food production through deconstructing the biomolecular interactions between feed, gut microorganisms and animals in relation to performance parameters

Objective

Optimising food production is not only of commercial interest for companies, but with the planet’s population approaching the nine billion mark, also of critical importance for humanity. Animal food production can be optimised by modulating animal-associated microbiomes through the use of feed additives such as prebiotics and probiotics. Previously developed feed additives have not acknowledged the specific means of action of the additives on the microbiome and host organisms, and consequently i) their performance is inconsistent across animals with different genetic background and when grown under different environments, ii) improvement of feed additives is inefficient and costly, and iii) optimal solutions are unlikely to be found without taking a more holistic approach. HoloFood showcases a holistic approach that will improve the efficiency of food production systems by deciphering the molecular and physiological processes triggered by feed additives across animals with different genetic background and grown under different environments. We will use two critically important farmed animal systems as our models -salmon and chicken- and characterise not only their associated microorganisms’ genomes, transcriptomes and metabolomes but also how the microbiome interacts with animals' genomes and transcriptomes within the new holo-omic framework in relation to key performance indices and animal welfare issues. The knowledge generated will be used to optimise feed additive administration strategies of already implemented products by tailoring them to the genetic background and developmental stage of the animals as well as production environment, to improve the quantity, quality and safety of the produced food, as well as sustainability of food production and animal welfare. HoloFood will also serve to raise awareness about the importance of microbiomes in food production, and to establish bridges between companies and academia to foster science-based strategies.
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Coordinator

KOBENHAVNS UNIVERSITET

Address

Norregade 10
1165 Kobenhavn

Denmark

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 3 760 266

Participants (9)

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UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA

Spain

EU Contribution

€ 671 610

NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU

Norway

EU Contribution

€ 1 531 250

FREIE UNIVERSITAET BERLIN

Germany

EU Contribution

€ 1 013 651,25

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 896 516,25

INSTITUT DE RECERCA I TECNOLOGIA AGROALIMENTARIES

Spain

EU Contribution

€ 307 187,50

HAVFORSKNINGSINSTITUTTET

Norway

EU Contribution

€ 781 495

CHR. HANSEN A/S

Denmark

EU Contribution

€ 468 414

LEROY SEAFOOD GROUP ASA

Norway

EU Contribution

€ 264 828

PIAST PASZE SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA

Poland

EU Contribution

€ 167 875

Project information

Grant agreement ID: 817729

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2022

Funded under:

H2020-EU.3.2.3.3.

H2020-EU.3.2.2.

  • Overall budget:

    € 10 825 325

  • EU contribution

    € 9 863 093

Coordinated by:

KOBENHAVNS UNIVERSITET

Denmark