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A need for speed: mechanisms to coordinate protein synthesis and folding in metazoans

Project description

Coordinating protein synthesis and folding in metazoans

To function, proteins fold into complex 3D shapes. Since proteins often begin to fold during messenger ribonucleic acid (mRNA) translation, codon choice and transfer ribonucleic acid (tRNA) supply can further this process by modulating translation speed. Scientists don’t know how metazoans exploit this mechanism to ensure protein homeostasis. The EU-funded TransTempoFold project will establish how tRNA pools and the regulatory networks for protein biogenesis and homeostasis are tailored to specialised proteomes in different cell types. It will focus on stem cells and differentiated progeny lines and develop a method to modulate cellular tRNA pools in vivo. The project will define how diverse metazoan cell proteomes are established and maintained and reveal why some cells tolerate misfolded proteins better than others.

Call for proposal

ERC-2018-STG
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Host institution

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Address
Hofgartenstrasse 8
80539 Munchen
Germany
Activity type
Research Organisations
EU contribution
€ 1 500 000

Beneficiaries (1)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 1 500 000
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations