New treatment for NAFLD when lifestyle modifications fail
Strongly associated with obesity, hypertension and type 2 diabetes, non-alcoholic fatty liver disease (NAFLD) represents an increasing global public health problem worldwide. This progressive liver disease affects up to 25 % of the EU population. With no FDA-approved drugs available to treat this condition, lifestyle modification is the cornerstone of management. But what happens when lifestyle modifications fail? In this context, the EU-funded BARINAFLD project will develop novel, weight-loss independent mechanisms that can lead to NAFLD alleviation and harness them to treat this disease. Specifically, it will combine bariatric surgery in mice and humans with advanced molecular and computational analyses. By comparing livers of lean patients to those of NAFLD patients before and shortly after bariatric surgery, the project will shed light on surgery-mimetic therapies for this disease.
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