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Using Bariatric Surgery to Discover Weight-Loss Independent Mechanisms Leading to the Reversal of Fatty Liver Disease

Project description

New treatment for NAFLD when lifestyle modifications fail

Strongly associated with obesity, hypertension and type 2 diabetes, non-alcoholic fatty liver disease (NAFLD) represents an increasing global public health problem worldwide. This progressive liver disease affects up to 25 % of the EU population. With no FDA-approved drugs available to treat this condition, lifestyle modification is the cornerstone of management. But what happens when lifestyle modifications fail? In this context, the EU-funded BARINAFLD project will develop novel, weight-loss independent mechanisms that can lead to NAFLD alleviation and harness them to treat this disease. Specifically, it will combine bariatric surgery in mice and humans with advanced molecular and computational analyses. By comparing livers of lean patients to those of NAFLD patients before and shortly after bariatric surgery, the project will shed light on surgery-mimetic therapies for this disease.

Call for proposal

ERC-2018-STG
See other projects for this call

Funding Scheme

ERC-STG - Starting Grant

Host institution

THE HEBREW UNIVERSITY OF JERUSALEM
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Israel
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 499 354

Beneficiaries (1)

THE HEBREW UNIVERSITY OF JERUSALEM
Israel
EU contribution
€ 1 499 354
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Activity type
Higher or Secondary Education Establishments