CORDIS
EU research results

CORDIS

English EN
Light and Organic Nanotechnology for Cardiovascular Disease

Light and Organic Nanotechnology for Cardiovascular Disease

Objective

Cardiovascular (CV) disease is the leading cause of mortality and morbidity worldwide, with an increasing incidence in the aging population and a huge socio-economical impact. Heart failure (HF), the common end point of virtually all CV disorders, displays the greatest negative impact on quality of life, leading to the disruption of daily management and increasing dependence on care-givers. Unfortunately, an effective pharmacological treatment is currently lacking, as it is not possible to reverse disease progression; as a consequence, the long-term survival remains poor, and heart transplantation is the only possibility for end-stage HF patients. Thus, a breakthrough approach to preserve or, at least, restore cardiovascular function and to rescue systemic blood perfusion is urgently required.
LION-HEARTED will demonstrate a novel optoceutic platform, based on synergistic combination of light and organic nanotechnology, to restore cardiac function and vascularization, by modulating fate and proliferation of main cardiovascular cell types. Optical modulation will provide unprecedented spatio-temporal resolution, lower invasiveness, and higher selectivity in respect to traditional electrical and pharmaceutical control methods. Organic semiconductors will act as efficient, highly biocompatible phototransducers, able to trigger biological pathways relevant to cardiac repair, with a minimally invasive and gene-less approach. This strategy will circumvent most of the hurdles currently limiting the efficacy of molecular therapies, by directly stimulating the reparative phenotype of resident cardiac progenitors, cardiomyocytes, and of circulating endothelial cells homing towards the heart after an ischemic insult. The final outcome will be the realization of a proof of concept, implantable device for enhancing cardiac repair in ischemic, aneurysm and stenosis in vivo animal models.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Address

Via Morego 30
16163 Genova

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 509 458,75

Participants (7)

Sort alphabetically

Sort by EU Contribution

Expand all

UNIVERSITA DEGLI STUDI DI PAVIA

Italy

EU Contribution

€ 305 000

HUMANITAS MIRASOLE SPA

Italy

EU Contribution

€ 450 000

TECHNISCHE UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 272 250

UNIVERSITAT LINZ

Austria

EU Contribution

€ 285 250

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA

Italy

EU Contribution

€ 279 250

UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA

Spain

EU Contribution

€ 313 475

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

EU Contribution

€ 489 730

Project information

Grant agreement ID: 828984

Status

Ongoing project

  • Start date

    1 May 2019

  • End date

    30 April 2023

Funded under:

H2020-EU.1.2.1.

  • Overall budget:

    € 2 904 413,75

  • EU contribution

    € 2 904 413,75

Coordinated by:

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Italy