Project description
An improved method for fluorinating aromatic compounds
Fluorinated arenes are an invaluable class of organic compounds with important applications in pharmaceuticals and agrochemicals. Fluorine-18 is used for arene labelling. This fluorine radioisotope is one of the early tracers used in positron emission tomography mainly due to its short half-life and the emission of positrons when decaying. Funded by the Marie Skłodowska-Curie Actions programme, the ElectroCatFlow project is developing a novel method to access aryl fluorides using a transition metal-catalysed fluorination reaction of aryl halides. The project aims to retain Europe's excellence in fluorination, catalysis and flow chemistry. The work will have a far-reaching impact on the pharmaceutical industry.
Objective
Fluorinated arenes are an invaluable class of organic compounds with important applications in pharmaceuticals, agrochemicals, and materials. Additionally, fluorine-18 has secured its place as the important radionuclide used in positron emission tomography (PET), largely due to attractive physical and nuclear characteristics. Through the years, use of transition-metal catalysis has revolutionised the access to these challenging compounds. However reliance on expensive catalysts and ligands, elevated temperatures, extended reaction times, and limited substrate scopes remain unsatisfied. This project untitled “Fluorination of Aryl Halide Compounds under Electrochemical-Flow Conditions” or “ElectroCatFlow” aims to develop a novel method to access aryl fluorides using a transition metal-catalysed fluorination reaction of aryl halides under electrochemical-flow conditions. ElectroCatFlow is highly interdisciplinary, involves mechanistic investigations, and applications of electrochemical-flow techniques to afford a mild, efficient and inexpensive method compared to current strategies. This project will generate broad interest from academia and industry, and will lead to high impact publications including scientific papers and potential patents. Finally, ElectroCatFLow will also maintain and improve European´s excellence in fluorination, catalysis and flow chemistry by creating a synergistic collaboration between the partner and institutions. Besides, this proposal aims to significantly influence on the EU healthcare system given the relevance of fluorine based drugs have in the Society.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences chemical sciences organic chemistry hydrocarbons
- natural sciences chemical sciences inorganic chemistry halogens
- natural sciences chemical sciences catalysis
- natural sciences chemical sciences nuclear chemistry radiation chemistry
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
5612 AE Eindhoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.