Networking for excellence in functional pharmacology to study the role of fatty acid metabolism in neurological disorders

Project Information

FAT4BRAIN

Grant agreement ID: 857394

DOI 10.3030/857394

Project closed

EC signature date 18 June 2019

Start date 1 November 2019

End date 30 April 2023

Funded under

• Twinning of research institutions

Total cost € 799 406,25

EU contribution € 799 406,25

Coordinated by

LATVIJAS ORGANISKAS SINTEZES INSTITUTS
Latvia

Deliverables

Documents, reports (15)

1st dissemination and communication report
Minutes from the 3rd year Executive Board meeting

Minutes from the FAT4BRAIN 3rd year Executive Board meeting

Report on organized events and trainings M1-12
Report on visits and participation in capacity-building events

Report on UU and EKUT researcher visits and participation in capacitybuilding events

Minutes from the 2nd year Executive Board meeting

Minutes from the FAT4BRAIN 2nd year Executive Board meeting

Strategy and plan for ESR involvement

Strategy and plan for ESR involvement in FAT4BRAIN activities and establishment of mentoring platform

Report on organized events and trainings M25-40

Report on organized events and trainings M2540

Report on LIOS researcher visits and participation in capacity-building events

Report on LIOS researcher visits and participation in capacitybuilding events

Minutes from the kick-off meeting
Communication channels and visual identity

Created FAT4BRAIN communication channels and visual identity

Communication Strategy and Plan of Exploitation and Dissemination of Results
Report on organized events and trainings M13-24

Report on organized events and trainings M1324

Report on researcher visits and participation in capacity-building events

Report on OROBOROS researcher visits and participation in capacitybuilding events

Minutes from the 1st year Executive Board meeting

Minutes from the FAT4BRAIN 1st year Executive Board meeting

2nd dissemination and communication report

Open Research Data Pilot (1)

Data management plan

Development of data management plan

Publications

Peer reviewed articles (25)

Effects of Transient Administration of the NMDA Receptor Antagonist MK-801 in Drosophila melanogaster Activity, Sleep, and Negative Geotaxis

Author(s): Moulin TC, Stojanovic T, Rajesh RP, Pareek T, Donzelli L, Williams MJ, Schiöth HB
Published in: Biomedicines, 2023, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines11010192

Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage

Author(s): Liepinsh E, Kuka J, Vilks K, Svalbe B, Stelfa G, Vilskersts R, Sevostjanovs E, Goldins NR, Groma V, Grinberga S, Plaas M, Makrecka-Kuka M, Dambrova M
Published in: Free Radical Biology and Medicine, 2021, ISSN 1873-4596
Publisher: Elsevier
DOI: 10.1016/j.freeradbiomed.2021.10.035

Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload

Author(s): Marina Makrecka-Kuka, Stanislava Korzh, Melita Videja, Karlis Vilks, Helena Cirule, Janis Kuka, Maija Dambrova, Edgars Liepinsh
Published in: Cardiovascular Drugs and Therapy, Issue 34/6, 2020, Page(s) 791-797, ISSN 0920-3206
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10557-020-06989-9

Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: Integrating the phenotypic, molecular and neuroanatomical dimensions

Author(s): Zümrüt Duygu Sen, Lena Vera Danyeli, Marie Woelfer, Femke Lamers, Gerd Wagner, Thomas Sobanski, Martin Walter
Published in: Brain, Behavior, and Immunity, Issue 93, 2021, Page(s) 335-352, ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2020.12.020

Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats

Author(s): Kuka J, Makrecka-Kuka M, Vilks K, Korzh S, Cirule H, Sevostjanovs E, Grinberga S, Dambrova M, Liepinsh E
Published in: Oxidative Medicine and Cellular Longevity, 2021, ISSN 1942-0994
Publisher: Hindawi
DOI: 10.1155/2021/7493190

Heart-Type Fatty Acid Binding Protein Binds Long-Chain Acylcarnitines and Protects against Lipotoxicity

Author(s): Zelencova-Gopejenko D, Videja M, Grandane A, Pudnika-Okinčica L, Sipola A, Vilks K, Dambrova M, Jaudzems K, Liepinsh E
Published in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24065528

Acylcarnitines: Nomenclature, biomarkers, therapeutic potential, drug targets and clinical trials

Author(s): Dambrova M, Makrecka-Kuka M, Kuka J, Vilskersts R, Nordberg D, Attwood M, Smesny S, Duygu Sen Z, Chi Guo A, Oler E, Tian S, Wishart D, Liepinsh E, Schiöth H
Published in: Pharmacological Reviews, 2022, ISSN 1521-0081
Publisher: ASPET
DOI: 10.1124/pharmrev.121.000408

Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury

Author(s): Stelfa G, Vavers E, Svalbe B, Serzants R, Miteniece A, Lauberte L, Grinberga S, Gukalova B, Dambrova M, Zvejniece L
Published in: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222111611

Multidrug Resistance Like Protein 1 Activity in Malpighian Tubules Regulates Lipid Homeostasis in Drosophila

Author(s): Liu W, Cao H, Kimari M, Maronitis G, Williams MJ, Schiöth HB
Published in: Membranes (Basel), 2021, ISSN 2077-0375
Publisher: Molecular Diversity Preservation International
DOI: 10.3390/membranes11060432

Transient Administration of Dopaminergic Precursor Causes Inheritable Overfeeding Behavior in Young Drosophila melanogaster Adults

Author(s): Moulin TC, Ferro F, Berkins S, Hoyer A, Williams MJ, Schiöth HB
Published in: Brain Sciences, 2020, ISSN 2076-3425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/brainsci10080487

Rodent Heart and Brain Tissue Preparation for Digital Macro Photography after Ischemia-reperfusion

Author(s): Liepinsh E, Kuka J, Zvejniece L, Vilskersts R, Dambrova M
Published in: Journal of visualized experiments, 2022, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/62942

Excitability, synaptic balance, and addiction: The homeostatic dynamics of ionotropic glutamatergic receptors in VTA after cocaine exposure

Author(s): Thiago C. Moulin, Helgi B. Schiöth
Published in: Behavioral and Brain Functions, Issue 16/1, 2020, ISSN 1744-9081
Publisher: BioMed Central
DOI: 10.1186/s12993-020-00168-4

Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster

Author(s): Schiöth HB, Donzelli L, Williams MJ, Moulin TC
Published in: Biology, 2023, ISSN 2079-7737
Publisher: MDPI
DOI: 10.3390/biology12040635

Sigma-1 receptor and seizures.

Author(s): Vavers E, Zvejniece L, Dambrova M
Published in: Pharmacological Research, 2023, ISSN 2667-1425
Publisher: Elsevier
DOI: 10.1016/j.phrs.2023.106771

Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria

Author(s): Marina Makrecka-Kuka, Kristine Volska, Unigunde Antone, Reinis Vilskersts, Solveiga Grinberga, Dace Bandere, Edgars Liepinsh, Maija Dambrova
Published in: Toxicology Letters, Issue 267, 2017, Page(s) 32-38, ISSN 0378-4274
Publisher: Elsevier BV
DOI: 10.1016/j.toxlet.2016.12.017

Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues

Author(s): Marina Makrecka-Kuka, Eduards Sevostjanovs, Karlis Vilks, Kristine Volska, Unigunde Antone, Janis Kuka, Elina Makarova, Osvalds Pugovics, Maija Dambrova, Edgars Liepinsh
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-17797-x

The activity of selective sigma-1 receptor ligands in seizure models in vivo

Author(s): Edijs Vavers, Baiba Svalbe, Lasma Lauberte, Ilmars Stonans, Ilga Misane, Maija Dambrova, Liga Zvejniece
Published in: Behavioural Brain Research, Issue 328, 2017, Page(s) 13-18, ISSN 0166-4328
Publisher: Elsevier BV
DOI: 10.1016/j.bbr.2017.04.008

Effects of the N-methyl-d-aspartate receptor antagonist, MK-801, on spatial memory and influence of the route of administration

Author(s): Baiba Svalbe, Gundega Stelfa, Edijs Vavers, Baiba Zvejniece, Solveiga Grinberga, Eduards Sevostjanovs, Osvalds Pugovics, Maija Dambrova, Liga Zvejniece
Published in: Behavioural Brain Research, Issue 372, 2019, Page(s) 112067, ISSN 0166-4328
Publisher: Elsevier BV
DOI: 10.1016/j.bbr.2019.112067

Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB

Author(s): Janis Kuka, Marina Makrecka-Kuka, Helena Cirule, Solveiga Grinberga, Eduards Sevostjanovs, Maija Dambrova, Edgars Liepinsh
Published in: Basic & Clinical Pharmacology & Toxicology, Issue 121/2, 2017, Page(s) 106-112, ISSN 1742-7835
Publisher: Nordic Pharmacological Society
DOI: 10.1111/bcpt.12775

Mitochondrial metabolites acylcarnitines: therapeutic potential and drug targets

Author(s): Dambrova M, Cecatto C, Vilskersts R, Liepinsh E
Published in: Bioenergetics Communications, 2022, ISSN 2791-4690
Publisher: BEC
DOI: 10.26124/bec:2022-0015

Rodent and fly models in behavioral neuroscience: An evaluation of methodological advances, comparative research, and future perspectives

Author(s): Moulin TC, Covill LE, Itskov PM, Williams MJ, Schiöth HB
Published in: Neuroscience & Biobehavioral Reviews, 2021, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2020.11.014

Neurological manifestations of COVID-19: A comprehensive literature review and discussion of mechanisms

Author(s): Johansson A, Mohamed MS, Moulin TC, Schiöth HB
Published in: Journal of Neuroimmunology, 2021, ISSN 1872-8421
Publisher: Elsevier
DOI: 10.1016/j.jneuroim.2021.577658

The Drosophila melanogaster Levodopa-Induced Depression Model Exhibits Negative Geotaxis Deficits and Differential Gene Expression in Males and Females

Author(s): Moulin TC, Ferro F, Hoyer A, Cheung P, Williams MJ, Schiöth HB
Published in: Frontiers in Neuroscience, 2021, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2021.653470

Acylcarnitines in health and disease: biomarkers and drug targets

Author(s): Dambrova M, Liepinsh E
Published in: Macedonian Pharmaceutical Bulletin, 2022, ISSN 1857-8969
Publisher: Skopje Makedonsko farmacevtsko društvo
DOI: 10.33320/maced.pharm.bull.2022.68.03.006

Sex differences in COVID-19: the role of androgens in disease severity and progression

Author(s): Mohamed S. Mohamed, Thiago C. Moulin, Helgi B. Schiöth
Published in: Endocrine, Issue 71/1, 2021, Page(s) 3-8, ISSN 1355-008X
Publisher: Springer Link
DOI: 10.1007/s12020-020-02536-6