Networking for excellence in functional pharmacology to study the role of fatty acid metabolism in neurological disorders

Información del proyecto

FAT4BRAIN

Identificador del acuerdo de subvención: 857394

DOI

10.3030/857394

Proyecto cerrado

Fecha de la firma de la CE 18 Junio 2019

Fecha de inicio 1 Noviembre 2019

Fecha de finalización 30 Abril 2023

Financiado con arreglo a

• Twinning of research institutions

Coste total

€ 799 406,25

Aportación de la UE

€ 799 406,25

Coordinado por

LATVIJAS ORGANISKAS SINTEZES INSTITUTS
Latvia

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (15)

1st dissemination and communication report
Minutes from the 3rd year Executive Board meeting

Minutes from the FAT4BRAIN 3rd year Executive Board meeting

Report on organized events and trainings M1-12
Report on visits and participation in capacity-building events

Report on UU and EKUT researcher visits and participation in capacitybuilding events

Minutes from the 2nd year Executive Board meeting

Minutes from the FAT4BRAIN 2nd year Executive Board meeting

Strategy and plan for ESR involvement

Strategy and plan for ESR involvement in FAT4BRAIN activities and establishment of mentoring platform

Report on organized events and trainings M25-40

Report on organized events and trainings M2540

Report on LIOS researcher visits and participation in capacity-building events

Report on LIOS researcher visits and participation in capacitybuilding events

Minutes from the kick-off meeting
Communication channels and visual identity

Created FAT4BRAIN communication channels and visual identity

Communication Strategy and Plan of Exploitation and Dissemination of Results
Report on organized events and trainings M13-24

Report on organized events and trainings M1324

Report on researcher visits and participation in capacity-building events

Report on OROBOROS researcher visits and participation in capacitybuilding events

Minutes from the 1st year Executive Board meeting

Minutes from the FAT4BRAIN 1st year Executive Board meeting

2nd dissemination and communication report

Open Research Data Pilot (1)

Data management plan

Development of data management plan

Publicaciones

Peer reviewed articles (25)

Effects of Transient Administration of the NMDA Receptor Antagonist MK-801 in Drosophila melanogaster Activity, Sleep, and Negative Geotaxis

Autores: Moulin TC, Stojanovic T, Rajesh RP, Pareek T, Donzelli L, Williams MJ, Schiöth HB
Publicado en: Biomedicines, 2023, ISSN 2227-9059
Editor: MDPI
DOI: 10.3390/biomedicines11010192

Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage

Autores: Liepinsh E, Kuka J, Vilks K, Svalbe B, Stelfa G, Vilskersts R, Sevostjanovs E, Goldins NR, Groma V, Grinberga S, Plaas M, Makrecka-Kuka M, Dambrova M
Publicado en: Free Radical Biology and Medicine, 2021, ISSN 1873-4596
Editor: Elsevier
DOI: 10.1016/j.freeradbiomed.2021.10.035

Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload

Autores: Marina Makrecka-Kuka, Stanislava Korzh, Melita Videja, Karlis Vilks, Helena Cirule, Janis Kuka, Maija Dambrova, Edgars Liepinsh
Publicado en: Cardiovascular Drugs and Therapy, Edición 34/6, 2020, Página(s) 791-797, ISSN 0920-3206
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10557-020-06989-9

Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: Integrating the phenotypic, molecular and neuroanatomical dimensions

Autores: Zümrüt Duygu Sen, Lena Vera Danyeli, Marie Woelfer, Femke Lamers, Gerd Wagner, Thomas Sobanski, Martin Walter
Publicado en: Brain, Behavior, and Immunity, Edición 93, 2021, Página(s) 335-352, ISSN 0889-1591
Editor: Academic Press
DOI: 10.1016/j.bbi.2020.12.020

Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats

Autores: Kuka J, Makrecka-Kuka M, Vilks K, Korzh S, Cirule H, Sevostjanovs E, Grinberga S, Dambrova M, Liepinsh E
Publicado en: Oxidative Medicine and Cellular Longevity, 2021, ISSN 1942-0994
Editor: Hindawi
DOI: 10.1155/2021/7493190

Heart-Type Fatty Acid Binding Protein Binds Long-Chain Acylcarnitines and Protects against Lipotoxicity

Autores: Zelencova-Gopejenko D, Videja M, Grandane A, Pudnika-Okinčica L, Sipola A, Vilks K, Dambrova M, Jaudzems K, Liepinsh E
Publicado en: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24065528

Acylcarnitines: Nomenclature, biomarkers, therapeutic potential, drug targets and clinical trials

Autores: Dambrova M, Makrecka-Kuka M, Kuka J, Vilskersts R, Nordberg D, Attwood M, Smesny S, Duygu Sen Z, Chi Guo A, Oler E, Tian S, Wishart D, Liepinsh E, Schiöth H
Publicado en: Pharmacological Reviews, 2022, ISSN 1521-0081
Editor: ASPET
DOI: 10.1124/pharmrev.121.000408

Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury

Autores: Stelfa G, Vavers E, Svalbe B, Serzants R, Miteniece A, Lauberte L, Grinberga S, Gukalova B, Dambrova M, Zvejniece L
Publicado en: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222111611

Multidrug Resistance Like Protein 1 Activity in Malpighian Tubules Regulates Lipid Homeostasis in Drosophila

Autores: Liu W, Cao H, Kimari M, Maronitis G, Williams MJ, Schiöth HB
Publicado en: Membranes (Basel), 2021, ISSN 2077-0375
Editor: Molecular Diversity Preservation International
DOI: 10.3390/membranes11060432

Transient Administration of Dopaminergic Precursor Causes Inheritable Overfeeding Behavior in Young Drosophila melanogaster Adults

Autores: Moulin TC, Ferro F, Berkins S, Hoyer A, Williams MJ, Schiöth HB
Publicado en: Brain Sciences, 2020, ISSN 2076-3425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/brainsci10080487

Rodent Heart and Brain Tissue Preparation for Digital Macro Photography after Ischemia-reperfusion

Autores: Liepinsh E, Kuka J, Zvejniece L, Vilskersts R, Dambrova M
Publicado en: Journal of visualized experiments, 2022, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/62942

Excitability, synaptic balance, and addiction: The homeostatic dynamics of ionotropic glutamatergic receptors in VTA after cocaine exposure

Autores: Thiago C. Moulin, Helgi B. Schiöth
Publicado en: Behavioral and Brain Functions, Edición 16/1, 2020, ISSN 1744-9081
Editor: BioMed Central
DOI: 10.1186/s12993-020-00168-4

Evidence for Prepulse Inhibition of Visually Evoked Motor Response in Drosophila melanogaster

Autores: Schiöth HB, Donzelli L, Williams MJ, Moulin TC
Publicado en: Biology, 2023, ISSN 2079-7737
Editor: MDPI
DOI: 10.3390/biology12040635

Sigma-1 receptor and seizures.

Autores: Vavers E, Zvejniece L, Dambrova M
Publicado en: Pharmacological Research, 2023, ISSN 2667-1425
Editor: Elsevier
DOI: 10.1016/j.phrs.2023.106771

Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria

Autores: Marina Makrecka-Kuka, Kristine Volska, Unigunde Antone, Reinis Vilskersts, Solveiga Grinberga, Dace Bandere, Edgars Liepinsh, Maija Dambrova
Publicado en: Toxicology Letters, Edición 267, 2017, Página(s) 32-38, ISSN 0378-4274
Editor: Elsevier BV
DOI: 10.1016/j.toxlet.2016.12.017

Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues

Autores: Marina Makrecka-Kuka, Eduards Sevostjanovs, Karlis Vilks, Kristine Volska, Unigunde Antone, Janis Kuka, Elina Makarova, Osvalds Pugovics, Maija Dambrova, Edgars Liepinsh
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-17797-x

The activity of selective sigma-1 receptor ligands in seizure models in vivo

Autores: Edijs Vavers, Baiba Svalbe, Lasma Lauberte, Ilmars Stonans, Ilga Misane, Maija Dambrova, Liga Zvejniece
Publicado en: Behavioural Brain Research, Edición 328, 2017, Página(s) 13-18, ISSN 0166-4328
Editor: Elsevier BV
DOI: 10.1016/j.bbr.2017.04.008

Effects of the N-methyl-d-aspartate receptor antagonist, MK-801, on spatial memory and influence of the route of administration

Autores: Baiba Svalbe, Gundega Stelfa, Edijs Vavers, Baiba Zvejniece, Solveiga Grinberga, Eduards Sevostjanovs, Osvalds Pugovics, Maija Dambrova, Liga Zvejniece
Publicado en: Behavioural Brain Research, Edición 372, 2019, Página(s) 112067, ISSN 0166-4328
Editor: Elsevier BV
DOI: 10.1016/j.bbr.2019.112067

Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB

Autores: Janis Kuka, Marina Makrecka-Kuka, Helena Cirule, Solveiga Grinberga, Eduards Sevostjanovs, Maija Dambrova, Edgars Liepinsh
Publicado en: Basic & Clinical Pharmacology & Toxicology, Edición 121/2, 2017, Página(s) 106-112, ISSN 1742-7835
Editor: Nordic Pharmacological Society
DOI: 10.1111/bcpt.12775

Mitochondrial metabolites acylcarnitines: therapeutic potential and drug targets

Autores: Dambrova M, Cecatto C, Vilskersts R, Liepinsh E
Publicado en: Bioenergetics Communications, 2022, ISSN 2791-4690
Editor: BEC
DOI: 10.26124/bec:2022-0015

Rodent and fly models in behavioral neuroscience: An evaluation of methodological advances, comparative research, and future perspectives

Autores: Moulin TC, Covill LE, Itskov PM, Williams MJ, Schiöth HB
Publicado en: Neuroscience & Biobehavioral Reviews, 2021, ISSN 0149-7634
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2020.11.014

Neurological manifestations of COVID-19: A comprehensive literature review and discussion of mechanisms

Autores: Johansson A, Mohamed MS, Moulin TC, Schiöth HB
Publicado en: Journal of Neuroimmunology, 2021, ISSN 1872-8421
Editor: Elsevier
DOI: 10.1016/j.jneuroim.2021.577658

The Drosophila melanogaster Levodopa-Induced Depression Model Exhibits Negative Geotaxis Deficits and Differential Gene Expression in Males and Females

Autores: Moulin TC, Ferro F, Hoyer A, Cheung P, Williams MJ, Schiöth HB
Publicado en: Frontiers in Neuroscience, 2021, ISSN 1662-453X
Editor: Frontiers
DOI: 10.3389/fnins.2021.653470

Acylcarnitines in health and disease: biomarkers and drug targets

Autores: Dambrova M, Liepinsh E
Publicado en: Macedonian Pharmaceutical Bulletin, 2022, ISSN 1857-8969
Editor: Skopje Makedonsko farmacevtsko društvo
DOI: 10.33320/maced.pharm.bull.2022.68.03.006

Sex differences in COVID-19: the role of androgens in disease severity and progression

Autores: Mohamed S. Mohamed, Thiago C. Moulin, Helgi B. Schiöth
Publicado en: Endocrine, Edición 71/1, 2021, Página(s) 3-8, ISSN 1355-008X
Editor: Springer Link
DOI: 10.1007/s12020-020-02536-6