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A diagnostic test to improve surveillance and care of COVID-19 patients

Objective

Coronavirus disease 2019 (COVID-19) caused by infection with SARS coronavirus 2 (SARS-CoV-2) has reached pandemic proportions with more than 7 million people infected and 0.4 million people killed worldwide. Death rates are accentuated by cardiovascular comorbidities and arrhythmias leading to unexpected major cardiovascular events. Being able to identify COVID-19 patients at risk of developing cardiovascular events leading to death would allow improving surveillance and care. Currently, there is no accurate method to predict outcome of COVID-19 patients. COVIRNA is a patient-centered Innovation Action aiming to satisfy this urgent and unmet need. COVIRNA will complete and deploy a prognostic system based on cardiovascular biomarkers of COVID-19 clinical outcomes combined with digital tools and artificial intelligence analytics (i.e. prediction model). Complementary expertise of 15 EU partners from the healthcare sector, academia, association and industry will allow conducting a large retrospective study on existing cohorts of COVID-19 patients. By upscaling the already validated and patented research use only FIMICS panel of cardiac-enriched long noncoding RNA biomarkers into an in-vitro diagnostic test (COVIRNA) adapted to COVID-19 patients, the project will quickly deliver a minimally-invasive, simple yet robust and affordable prognosis tool that can be used in the context of the current COVID-19 crisis as well as in further major health issues. By tackling the cardiovascular complications in COVID-19, known to contribute significantly to mortality, the project outputs are expected to have a major impact on the pandemic outcomes. The COVIRNA test will be CE-marked and prepared for commercialization, allowing to risk stratify patients, adapt therapies and to inform drug design.

Call for proposal

H2020-SC1-PHE-CORONAVIRUS-2020-2

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Sub call

H2020-SC1-PHE-CORONAVIRUS-2020-2-CNECT

Coordinator

LUXEMBOURG INSTITUTE OF HEALTH
Net EU contribution
€ 652 271,25
Address
Val Fleuri 84
1526 Luxembourg
Luxembourg

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Region
Luxembourg Luxembourg Luxembourg
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (15)

FIRALIS
France
Net EU contribution
€ 500 733,63
Address
Rue Du Fort 35
68330 Huningue

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Grand Est Alsace Haut-Rhin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 214 600,12
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

FIRALIS MOLECULAR PRECISION S.A.
France
Net EU contribution
€ 608 853,87
Address
17 Rue Du Fort
68330 Huningue

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Grand Est Alsace Haut-Rhin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 260 937,38
UNIVERSITE DU LUXEMBOURG
Luxembourg
Net EU contribution
€ 199 603,75
Address
2 Avenue De L'universite
4365 Esch-sur-alzette

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Region
Luxembourg Luxembourg Luxembourg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Net EU contribution
€ 400 000,00
Address
South Kensington Campus Exhibition Road
SW7 2AZ London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITEIT MAASTRICHT
Netherlands
Net EU contribution
€ 154 625,00
Address
Minderbroedersberg 4
6200 MD Maastricht

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Region
Limburg (NL) Zuid-Limburg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
EUROPEAN HEALTH MANAGEMENT ASSOCIATION
Belgium
Net EU contribution
€ 151 625,00
Address
Rue Belliard 15-17
1040 Bruxelles

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Other
Non-EU contribution
€ 0,00
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
Net EU contribution
€ 50 000,00
Address
Universitaetsstrasse 1
40225 Dusseldorf

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Region
Nordrhein-Westfalen Düsseldorf Düsseldorf, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE UNIVERSITY OF EDINBURGH
United Kingdom
Net EU contribution
€ 299 950,00
Address
Old College, South Bridge
EH8 9YL Edinburgh

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Region
Eastern Scotland Edinburgh
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INTERNACIONALNI UNIVERZITET U SARAJEVU
Bosnia and Herzegovina
Net EU contribution
€ 50 000,00
Address
Ul Hrasnicka Cesta 15
71210 Ilidza Sarajevo

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
POLICLINICO SAN DONATO SPA
Italy
Net EU contribution
€ 174 387,50
Address
Via Rodolfo Morandi 30
20097 San Donato Mi

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Region
Nord-Ovest Lombardia Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 74 737,50
PHARMAHUNGARY 2000 KISERLETES ES KLINIKAI KUTATASFEJLESZTESI KORLATOLTFELELOSSEGU TARSASAG
Hungary
Net EU contribution
€ 35 000,00
Address
Hajnoczy Utca 6 1 Em 1
6722 Szeged

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Alföld és Észak Dél-Alföld Csongrád
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 15 000,00
UNIVERSITAET LEIPZIG
Germany
Net EU contribution
€ 247 447,25
Address
Ritterstrasse 26
04109 Leipzig

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Region
Sachsen Leipzig Leipzig
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTITUT JOZEF STEFAN
Slovenia
Net EU contribution
€ 50 000,00
Address
Jamova 39
1000 Ljubljana

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Region
Slovenija Zahodna Slovenija Osrednjeslovenska
Activity type
Research Organisations
Non-EU contribution
€ 0,00
INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU FUNDACION
Spain
Net EU contribution
€ 250 000,00
Address
C Sant Quinti 77-79
08041 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSIDADE DE COIMBRA
Portugal
Net EU contribution
€ 50 000,00
Address
Paco Das Escolas
3004-531 Coimbra

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Region
Continente Centro (PT) Região de Coimbra
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00