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A diagnostic test to improve surveillance and care of COVID-19 patients

Objective

Coronavirus disease 2019 (COVID-19) caused by infection with SARS coronavirus 2 (SARS-CoV-2) has reached pandemic proportions with more than 7 million people infected and 0.4 million people killed worldwide. Death rates are accentuated by cardiovascular comorbidities and arrhythmias leading to unexpected major cardiovascular events. Being able to identify COVID-19 patients at risk of developing cardiovascular events leading to death would allow improving surveillance and care. Currently, there is no accurate method to predict outcome of COVID-19 patients. COVIRNA is a patient-centered Innovation Action aiming to satisfy this urgent and unmet need. COVIRNA will complete and deploy a prognostic system based on cardiovascular biomarkers of COVID-19 clinical outcomes combined with digital tools and artificial intelligence analytics (i.e. prediction model). Complementary expertise of 15 EU partners from the healthcare sector, academia, association and industry will allow conducting a large retrospective study on existing cohorts of COVID-19 patients. By upscaling the already validated and patented research use only FIMICS panel of cardiac-enriched long noncoding RNA biomarkers into an in-vitro diagnostic test (COVIRNA) adapted to COVID-19 patients, the project will quickly deliver a minimally-invasive, simple yet robust and affordable prognosis tool that can be used in the context of the current COVID-19 crisis as well as in further major health issues. By tackling the cardiovascular complications in COVID-19, known to contribute significantly to mortality, the project outputs are expected to have a major impact on the pandemic outcomes. The COVIRNA test will be CE-marked and prepared for commercialization, allowing to risk stratify patients, adapt therapies and to inform drug design.

Call for proposal

H2020-SC1-PHE-CORONAVIRUS-2020-2-CNECT
See other projects for this call

Funding Scheme

IA - Innovation action

Coordinator

LUXEMBOURG INSTITUTE OF HEALTH
Address
Val Fleuri 84
1526 Luxembourg
Luxembourg
Activity type
Research Organisations
EU contribution
€ 652 271,25

Participants (14)

FIRALIS
France
EU contribution
€ 1 109 587,50
Address
Rue Du Fort 35
68330 Huningue
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITE DU LUXEMBOURG
Luxembourg
EU contribution
€ 199 603,75
Address
2 Avenue De L'universite
4365 Esch-sur-alzette
Activity type
Higher or Secondary Education Establishments
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 400 000
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 154 625
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
EUROPEAN HEALTH MANAGEMENT ASSOCIATION
Belgium
EU contribution
€ 151 625
Address
Rue Belliard 15-17
1040 Bruxelles
Activity type
Other
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
EU contribution
€ 50 000
Address
Universitaetsstrasse 1
40225 Dusseldorf
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 299 950
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
INTERNACIONALNI UNIVERZITET U SARAJEVU
Bosnia and Herzegovina
EU contribution
€ 50 000
Address
Ul Hrasnicka Cesta 15
71210 Ilidza Sarajevo
Activity type
Higher or Secondary Education Establishments
POLICLINICO SAN DONATO SPA
Italy
EU contribution
€ 174 387,50
Address
Via Rodolfo Morandi 30
20097 San Donato Mi
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PHARMAHUNGARY 2000 KISERLETES ES KLINIKAI KUTATASFEJLESZTESI KORLATOLTFELELOSSEGU TARSASAG
Hungary
EU contribution
€ 35 000
Address
Hajnoczy Utca 6 1 Em 1
6722 Szeged
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITAET LEIPZIG
Germany
EU contribution
€ 247 447,25
Address
Ritterstrasse 26
04109 Leipzig
Activity type
Higher or Secondary Education Establishments
INSTITUT JOZEF STEFAN
Slovenia
EU contribution
€ 50 000
Address
Jamova 39
1000 Ljubljana
Activity type
Research Organisations
INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU FUNDACION
Spain
EU contribution
€ 250 000
Address
C Sant Quinti 77-79
08041 Barcelona
Activity type
Research Organisations
UNIVERSIDADE DE COIMBRA
Portugal
EU contribution
€ 50 000
Address
Paco Das Escolas
3001 451 Coimbra
Activity type
Higher or Secondary Education Establishments