Project description
Promoting European excellence in organic synthesis and catalysis
The goal of the PhotoPhos project, which received funding under the Marie Skłodowska-Curie Actions programme, is to enhance European excellence in organic synthesis and catalysis. The project will equip the researcher with new skills in organophosphorus chemistry, electron donor-acceptor complexes and metal-free reactions. The researcher will also develop new drug candidates in collaboration with a partner pharmaceutical company. The project will leverage a newly developed synthetic method for photoinduced C-B bond formation that does not involve the use of photocatalysts and metals.
Objective
This proposed Fellowship brings together an Experienced Researcher from India (Ph.D. in Germany and Postdoc in Japan with an excellent academic and research background), with expertise in photocatalysis, methodology, and total synthesis, with an internationally recognized Host Laboratory in the UK under the expert supervision of Prof. Varinder K. Aggarwal FRS. His research interests focus on total synthesis, asymmetric synthesis, photoredox-driven processes, and the development of new reactivity in organic chemistry, in particular, boron chemistry.
The successful realization of this highly interdisciplinary project will:
➢Enhance European excellence in organic synthesis and catalysis, which are fundamentally important branches of chemistry.
➢Enable the ER to acquire new skills in the field of organophosphorus chemistry, EDA complexes, metal-free reactions, and to develop new drug candidates in collaboration with a partner pharmaceutical company, which will expand his scientific knowledge and network.
This proposed phosphorylation project is based on a new synthetic method recently developed in the host laboratory for photoinduced C-B bond formation under photocatalyst- and metal-free conditions. The proposed methodology will access highly valuable α-aminophosphonic acids from feedstock α-amino carboxylic acids, through a decarboxylative phosphorylation process driven by visible light. α-Aminophosphonic acids are used as antibiotics, herbicides, antitumor agents, and enzyme inhibitors, with broad applications in many areas of agriculture and medicine. To maximize the impact and application of the proposed decarboxylative phosphorylation in organic synthesis, enantioselective variants will also be developed to provide highly valuable enantioenriched α-aminophosphonic acids. Initially, an auxiliary approach with a chiral phosphorylating reagent will be used, before the extension to an enantioselective catalytic process using a chiral Brønsted acid catalyst.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences chemical sciences catalysis photocatalysis
- natural sciences chemical sciences organic chemistry organic acids
- natural sciences chemical sciences inorganic chemistry metalloids
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
BS8 1QU BRISTOL
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.