Project description
Brain organoid-on-chip for studying neocortical development
Brain organoids as a human model platform to understand neurodevelopmental are promising, but to date still have limited capacity to recapitulate human neocortical development and are hampered by high variability. To address the limitations and study neocortical development, the EU-funded BROOC project will apply microfluidic technology to develop an organ-on-chip (OoC) model of human neocortical development to control apicobasal polarity establishment. The project aims to improve the reproducibility of neocortical differentiation with well-defined and precisely controllable culturing parameters. This OoC platform will enable recapitulation of the complex microstructure of the native neocortex and provide a tool to study the molecular mechanisms of neocortical development and function and serve as an alternative to the use of animals.
Objective
A human model of neocortical development to understand neurodevelopmental disorders such as autism spectrum disorders or intellectual disability is urgently needed. Neural 2D cultures derived for example from induced pluripotent stem cells (iPSC) have been used for many years but lack the complexity of the tissue environment essential for the functionality of the developing neocortex.
A promising approach to provide controlled microenvironments that generate physiological conditions and allow controlled 3D spatio-temporal structuring is the use of Organ-on-chip (OoC) technology. This BROOC proposal aims to establish a new generation of Brain Organoid-on-Chip. To study neocortical development and test pharmaceutical interventions, this project will construct new cerebral organoid model with multi-layered cortical structures on microfluidic chip system within integrated electrode array. Moreover, the Brain Organoid-on-Chip platform has the potential to transform the field and will have many applications especially for studying neurodevelopmental disorders. By overcoming several drawbacks of currently available cerebral organoid models, it will impact on the emerging field of organoids in general spanning from organoids used as alternative methods for animal experiments to cerebral organoids generated from diverse species used as a tool to study the molecular mechanisms of brain evolution.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
72074 Tuebingen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.