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Biomarker and AI-supported FX06 therapy to prevent progression from mild and moderate to severe stages of COVID-19

Objective

More than 2.7 million hospitalisations of COVID-19-infected patients have occurred in Europe alone since the outbreak of the coronavirus in 2020. An average 14% of those patients with mild or moderate illness develop severe symptoms and are eventually admitted to the Intensive Care Unit (ICU). The most common treatment of patients in the first two stages of the illness, such as remdesivir and antibody therapies, have neither shown the desired effect nor prevented the progression of the disease to severe and critical stages of the illness.

Interventions against SARS-CoV-2 are in high need to prevent admissions to ICUs, and would reduce the burden on patients and their families, clinical staff and the healthcare sector. Additionally, such interventions would help to provide ICU beds for non-Covid patients requiring immediate interventions, such as for heart or cancer surgery, both of which are often in need of planned free ICU beds.

In COVend, our multidsciplinary consortium will deliver a new effective therapy against SARS-CoV-2 for the clinical management of the COVID-19 disease during mild and moderate stages, including for the prevention of disease progression to severe illness. This will be achieved by advancing a promising therapeutic candidate, FX06, from Technology Readiness Level (TRL) 7 to TRL9 through a multi-centre phase II/III clinical trial. COVend will study the influence of COVID-19 on endothelial cells (ECs) and the potential protective effect of FX06, and will apply -omics technologies, generate new algorithms and open-source software to carry out data analytics and modelling, and will develop health economic models to assess the socio-economic benefits and cost effectiveness of the new therapy. The COVend consortium unites expertise from different disciplines, including (cell) biology, ICT expertise for AI-based evaluations, pharma, economics and social sciences, as well as clinical expertise from 13 European countries.

Coordinator

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Net EU contribution
€ 1 453 547,50
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Germany

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 453 547,50

Participants (17)

ACCELOPMENT SCHWEIZ AG
Switzerland
Net EU contribution
€ 371 500,00
Address
Seefeldstrasse 198
8008 Zurich

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 371 500,00
EUROPEAN SOCIETY OF ANAESTHESIOLOGY AND INTENSIVE CARE AISBL
Belgium
Net EU contribution
€ 1 154 200,00
Address
Rue Des Comediens 24
1000 Bruxelles

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Other
Other funding
€ 1 154 200,00
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 2 213 872,50
Address
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 2 213 872,50
F4-PHARMA GES M B H
Austria
Net EU contribution
€ 2 622 750,00
Address
Gersthoferstrasse 103/23
1180 Wien

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Region
Wien Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 2 622 750,00
TAMPEREEN KORKEAKOULUSAATIO SR
Finland
Net EU contribution
€ 314 200,00
Address
Kalevantie 4
33100 Tampere

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Region
Manner-Suomi Länsi-Suomi Pirkanmaa
Activity type
Higher or Secondary Education Establishments
Other funding
€ 314 200,00
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
Net EU contribution
€ 403 032,50
Address
Belfield
4 Dublin

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 403 032,50
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
Net EU contribution
€ 325 625,00
Address
Hanzeplein 1
9713 GZ Groningen

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Region
Noord-Nederland Groningen Overig Groningen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 325 625,00
MEDICAL INTELLIGENT DATA ANALYTICS
Germany
Net EU contribution
€ 236 250,00
Address
Moselstrasse 27
60329 Frankfurt Am Main

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Region
Darmstadt Frankfurt am Main, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 236 250,00
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Germany
Net EU contribution
€ 142 500,00
Address
Josef-schneider-strasse 2
97080 Wurzburg

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Region
Bayern Unterfranken Würzburg, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 142 500,00
AZIENDA SOCIO-SANITARIA TERRITORIALE FATEBENEFRATELLI SACCO
Italy
Net EU contribution
€ 97 500,00
Address
Via Giovanni Battista Grassi 74
20157 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 97 500,00
UNIVERSITA DEGLI STUDI DI PERUGIA
Italy
Net EU contribution
€ 97 500,00
Address
Piazza Dell Universita 1
06123 Perugia

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Region
Centro (IT) Umbria Perugia
Activity type
Higher or Secondary Education Establishments
Other funding
€ 97 500,00
LIETUVOS SVEIKATOS MOKSLU UNIVERSITETO LIGONINE KAUNO KLINIKOS
Lithuania
Net EU contribution
€ 112 500,00
Address
Eiveniu 2
50009 Kaunas

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Region
Lietuva Vidurio ir vakarų Lietuvos regionas Kauno apskritis
Activity type
Research Organisations
Other funding
€ 112 500,00
INSTITUT CATALA DE LA SALUT
Spain
Net EU contribution
€ 112 500,00
Address
Gran Via De Les Corts Catalanes 587
08007 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 112 500,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Spain
Net EU contribution
€ 0,00
Address
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSITATEA DE MEDICINA SI FARMACIE CAROL DAVILA DIN BUCURESTI
Romania
Net EU contribution
€ 82 500,00
Address
Dionisie Lupu 37
020021 Bucuresti

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Region
Macroregiunea Trei Bucureşti-Ilfov Bucureşti
Activity type
Higher or Secondary Education Establishments
Other funding
€ 82 500,00
CENTRO HOSPITALAR E UNIVERSITARIO DE COIMBRA EPE
Portugal
Net EU contribution
€ 112 500,00
Address
Av De Bissaya, Praceta De Mota Pinto
3000-075 Coimbra

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Region
Continente Centro (PT) Região de Coimbra
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 112 500,00
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
Net EU contribution
€ 142 500,00
Address
3 Avenue Victoria
75000 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 142 500,00