Objective
Major Depressive Disorder (MDD) is a highly prevalent and disabling condition experienced by ~6% of the population worldwide. Interestingly, women are twice as likely as men to suffer from MDD, and the specific mechanisms contributing to such difference are only starting to be elucidated. Chronic mild stress has been shown to reproduce in rodents some of the main traits of MDD, such as anhedonia or anxiety-like behaviour. Chronic stress has been shown to interfere with prepronociceptin (Pnoc) expression in the anterior BNST (amBNST) in rodents. Interestingly, it has been established a functional antagonistic role of Pnoc neurons over corticotropin-releasing hormone (CRH)-expressing neurons, which mediate the stress response in mammals. Moreover, amBNSTPnoc neurons have been shown to support rapid arousal responses toward motivationally salient stimuli in mice. Preliminary data has demonstrated sex differences in amBNSTPnoc distribution across compartments, indicating possible sex-dependent effects of stress on amBNSTPnoc function. We aim to explore sex differences in amBNSTPnoc neurons in rapid arousal responses upon sucrose presentation and its relationship with chronic stress-driven anhedonia. To that end, rapid arousal responses in male and female mice will be studied after chronic stress in mice, and related to anhedonic-like behaviour, and Pnoc and CRH expression in compartments of the BNST. To further understand the effects of chronic stress in Pnoc neurons, calcium transients using 2-photon calcium imaging in amBNSTPnoc neurons will be studied before and after chronic stress. Chemogenetic activation of amBNSTPnoc after stress will be used to functionally test that low Pnoc expression drives hypoarousal states related to anhedonic behavior. The proposal aims to elucidate sex differences in the pathophysiology of chronic stress-driven depressive-like behaviour and provide new perspectives and ideas on the higher prevalence and treatment resistance in females.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine physiology pathophysiology
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences biological sciences zoology mammalogy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
08193 Cerdanyola Del Valles
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.