Objective
Multiple human diseases ranging from neurodegenerative disorders (such as Alzheimer´s disease) to cancer have been found to be linked with biomolecular mechanical properties change (phase transitions PTs). While these diseases have impacted many human beings (50 million for only AD), the causes of most of these diseases are still mysterious, and there is yet no effective treatment. To understand the pathological role of PTs and their corresponding potential as a therapeutic target for these diseases, it is crucial to probe the mechanical properties of live cells. Current standard approaches to measuring the mechanical properties have important limitations: requirement of contact force (atomic force microscopy and optical coherence elastography) and lack of cellular resolution (ultrasound and magnetic resonance imaging). An emerging tool, Brillouin microscopy (BM), provides the capability of “imaging” the mechanical properties through probing the so-called Brillouin scattering spectrum in a non-invasive manner with 3D sub-cellular resolution. Its advent has led to a wide range of biological applications. However, the acquisition time for a standard confocal microscope size image is in the order of tens of minutes, owing to the trade-off between the measurement speed and the spectral resolution. Thus, it prevents the BMs from studying the kinetics of phase transitions in live cells. FaBriCATion is to substantially investigate in-vivo Brillouin microscopy, pushing the acquisition time to a sub-millisecond scale per spectrum while maintaining the high spectral resolution, therefore permitting the measurements of the dynamic changes in mechanical properties of the living cells and tissues in sub-cellular resolution. It will enable direct observations of biomolecular phase transitions and reveal their relationship with the pathological effects in cells. The project will advance the research in understanding biomolecular PTs, thus bringing economic and societal benefits.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project has not yet been classified with EuroSciVoc.
Be the first one to suggest relevant scientific fields and help us improve our classification service
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
16163 Genova
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.