Project description
Targeted nanotherapy for lasting relief of arthritis
Arthritis is a common condition that causes chronic pain, stiffness, and limited movement. While anti-inflammatory drugs and steroids can relieve symptoms, these treatments often come with long-term side effects and do not stop disease progression. This means that many patients rely on lifelong medication, creating both health risks and financial strain. The EU-funded DesiRTA project aims to develop a new therapy that targets the root causes of arthritis. Researchers in Ireland and Portugal are designing a gold nanoparticle-based system to deliver gene-silencing molecules directly to inflamed joints, offering a controlled, side-effect-free alternative for lasting relief.
Objective
Arthritis is a common metabolic and immune associate disease that causes chronic pain and inflammation in a joint. Approximately
312 million people are affected by arthritis globally. It affects adults of all ages, both sexes, and all races and ethnicities, but the
prevalence in women is more than in men. Professional organizations have established many arthritis treatment regimens and
management guidelines; in those nonsteroidal anti-inflammatory drugs (NSAIDs), steroids and biologicals are the main ones. These are
effective against the disease aggressiveness and pain up to some extent, but the problem is this treatment is only symptomatic and
requires taking them lifelong; in that case, these drugs cause severe health problems and again increase the economic burden. For
these reasons, we need to develop a therapeutic technique and medication that can eliminate the symptom and causes of the disease
forever and prevent the ever-increasing number of patients worldwide. DesiTRA projects are an effort in the same vein to develop an
effective therapeutic alternative for arthritis that will avoid the aggravation of disease symptoms and cause of the disease together,
without causing any health-associated side effects. In this, mainly gold nanoparticle (AuNPs) conjugated siRNA will be delivered at the
disease site locally. Modified polysaccharides will increase the stability and release rate of AuNPs-siRNA, and these assemblies will be
delivered very controlled and precisely through a synovial fluid mimicking the shear-thinning hydrogel system. The ambitious
project will be conducted at two different groups and laboratories in Ireland and Portugal. The project involves experienced
researchers of other but related areas that will allow applicants to work in multidisciplinary aspects. The prestigious fellowship will
provide a plate form of renowned subject experts, and exposure to international collaborators will provide a unique opportunity to
grow as a true researcher
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine rheumatology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- social sciences sociology anthropology ethnology
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- engineering and technology nanotechnology nano-materials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
- Limerick
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.