Objective
Leaves show a large scale of morphological diversity. Advanced time-lapse imaging and computational analysis revealed specific growth differences underlying development of different leaf forms in the simple leaves of A. thaliana vs the complex leaves of its relative C. hirsuta. However, this does not capture the differences in genetic networks that underlie these growth changes during development. To solve this problem, I will apply state-of-the-art single cell technologies to dissect the genetic networks behind leaf development and complexity. First, by utilizing multimodal single cell sequencing technologies in high temporal resolution, I will describe the cell-type specific gene regulatory networks (GRNs) during leaf development. By comparing these cell types and GRNs between A. thaliana and C. hirsuta we will be able to make major steps on understanding mechanisms underlying development and diversity of leaf forms.
To understand how the newly discovered GRNs interact in a developing tissue context I will apply spatial transcriptomics to understand how local genetic changes can influence morphogenesis. To analyze this, I will implement a novel functionality in a software, MorhoGraphX, which was originally developed for microscopy-based growth analysis. This way, it will be possible to directly link the genetic regulators to cellular morphological properties.
A selected number of these regulators will be further investigated with comparative genetic methods empowered by gene editing.To further extend the findings and place them into a broader evolutionary perspective, I will investigate cell type specific GRNs in two Solanaceae species, one with simple (pepper) and one with complex leaves (tomato).By comparing the commonalities and differences between simple and complex leaves in Brassicaceae and Solanaceae, which occurred independently during evolution, we can reveal developmental and evolutionary constrains underlying differences between simple and complex leaf.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.