Project description
Revolutionising structural biology for viral defence
Recent viral threats underscore the urgency to confront emerging viruses with enhanced preparedness. A deeper understanding of the dynamic intricacies of viral structures is key. At the crossroads of viral evolution and medical response, a pivotal challenge arises: the need of expertise spanning theoretical understanding, instrument development, and application in the realm of structural biology for protein-drug interactions. In this context, the MSCA-funded SPIDoc’s project aims to enhance our understanding of viral structures. Merging mass spectrometry with light sources will offer unprecedented insights through X-ray based single particle imaging (SPI), among other approaches. Overall, the goal is to train a new generation of scientists, and pioneer data management standards.
Objective
SPIDoc’s DN stems from the need to prepare for emerging viruses enabling a fast response, as became evident lately. Basically, better knowledge of the dynamic nature of viral structures is required and fundamental to combat with appropriate treatments. In this perspective, several technologies were developed for structural biology, including a cutting-edge approach combining mass spectrometry (MS) and X-rays for single particle imaging (SPI) in MS SPIDOC. Despite these advances, a major bottleneck that the scientific community will face in coming years will be the lack of expertise with a broad knowledge from theory, instrument development and application relevant to structural biology with MS.
SPIDoc’s therefore aims to train the next generation of scientists with such expertise by a dedicated intersectoral training programme. SPIDoc’s projects are highly interlinked and the proposed training programme aims to provide the doctoral candidates with the basic and advanced knowledge to build a common interdisciplinary language, to work in teams and to acquire deep knowledge by a combination of lectures and practical sessions. An important aspect will be given to data management and the establishment of currently lacking standards for native MS metadata.
The research training is complemented by transferrable skills courses, setting the basis for progressing through the doctoral studies as well as for future career progression. Within these modules, training on equal opportunities and unconscious bias are included, shaping the future generation towards creating fair workplaces. Special attention will be paid to green-practice measures from the everyday practice in laboratories and offices up to the institutional level. By including developments from computational theory to instrumentation, the SPIDoc’s beneficiaries and associated partners will closely work together to advance cutting-edge technologies and apply them towards fast response.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences chemical sciences analytical chemistry mass spectrometry
- natural sciences biological sciences molecular biology structural biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-DN-01
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23562 Lubeck
Germany
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Participants (7)
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1081 HV Amsterdam
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22607 Hamburg
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69622 Villeurbanne Cedex
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751 05 Uppsala
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142 00 PRAHA 4
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1322 AM ALMERE
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Participation ended
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57076 Siegen
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Partners (10)
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17489 Greifswald
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152 32 CHALANDRI
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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M13 9PL Manchester
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116 36 Praha 1
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20251 Hamburg
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9712CP Groningen
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OX14 4RZ ABINGDON OXFORDSHIRE
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94025 Menlo Park
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69117 Heidelberg
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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22869 Schenefeld
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