Project description
Fluorescent guide stars enable control of light in biological tissues
The interaction of light and matter is an essential process for non-invasive biomedical tissue studies. However, physiological motion and scattering can pose significant challenges. So-called optical phase conjugation can reconstruct images created under these conditions, but approaches based on fluorescence currently require a single laser-based ‘guide star’. With the support of the Marie Skłodowska-Curie Actions programme, the FLUO.OPC project aims to improve the performance of such approaches and achieve active control of light through scattering media by exploiting multiple or extended fluorescent guide stars. The innovative approach will combine an advanced holographic technique and an optical phase conjugation.
Objective
Generating a complex optical excitation pattern through biological tissue is of great importance for non-invasive biomedical studies. However, for many biological applications, our ability to control light is greatly limited by multiple scattering and physiological motions. While optical phase conjugation has potential to overcome these challenges, techniques based on fluorescence are still at an immature stage, requiring a single isolated guide star. Exploiting multiple or extended fluorescent guide stars will greatly benefit a wide range of applications, such as deep tissue optogenetics, because of the availability and targeted labeling of fluorescent probes. The goal of this proposal is to achieve active control of light through scattering media using multiple or extended fluorescent guide stars via advanced holographic technique and optical phase conjugation, and test its viability for biological tissue.
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Keywords
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75006 Paris
France
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