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Bacterial Methionine Oxidation Repair and Aging

Objective

Identifying the causal molecular processes of aging is a long-standing quest in biology. Oxidative stress is a conserved hallmark of senescence among living organisms, but the underlying mechanisms linking oxidative damage and aging have proved difficult to unravel.

Multiple reports pinpoint Methionine oxidation as an important antioxidant system influencing the lifespan of cells. Here, I propose to develop an approach including single-particle tracking and microfludic-based single-cell imaging to visualise Methionine oxidation repair in live E. coli bacteria. Such method is currently lacking in the field and its development, although challenging, could deepen our understanding of how system-level failures emerge out of molecular damage.

Fields of science (EuroSciVoc)

Keywords

Programme(s)

Topic(s)

Funding Scheme

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

(opens in new window) HORIZON-MSCA-2022-PF-01

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Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Net EU contribution
€ 211 754,88
Address
RUE MICHEL ANGE 3
75794 Paris
France
Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
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Total cost
No data