Bacterial Methionine Oxidation Repair and Aging

Project Information

MOR-AGE

Grant agreement ID: 101106503

DOI

10.3030/101106503

Project closed

EC signature date 22 March 2023

Start date 1 May 2023

End date 30 April 2025

Funded under

• Marie Skłodowska-Curie Actions (MSCA)

Total cost

No data

EU contribution

€ 211 754,88

Coordinated by

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

Periodic Reporting for period 1 - MOR-AGE (Bacterial Methionine Oxidation Repair and Aging)

Reporting period: 2023-05-01 to 2025-04-30

Summary of the context and overall objectives of the project

Cells are constantly exposed to oxidative stress, which can damage essential molecules and affect their survival. Among the molecules targeted, proteins are particularly vulnerable. The MOR-AGE project aimed to better understand how bacteria repair oxidative damage in proteins, and how this process influences their capacity to cope with stress and age over time.

Work performed from the beginning of the project to the end of the period covered by the report and main results achieved so far

During the project, advanced microscopy and genetic tools were developed to observe in real time how bacteria respond to oxidative stress. These tools made it possible to measure how protein repair mechanisms are activated and how they vary from one cell to another. The project also explored how these processes affect bacterial growth and survival under challenging conditions.

Progress beyond the state of the art and expected potential impact (including the socio-economic impact and the wider societal implications of the project so far)

The project produced new tools and experimental approaches to study protein oxidation and its physiological consequences at the single-cell level. These results go beyond the current state of the art by offering new ways to study how cells adapt to their environment and manage internal damage.

Single-cell imaging of E. coli under oxidative attacks