Project description
Soft neural probes development
The peripheral nervous system (PNS) is a complex network of nerves that transmits information from the brain and spinal cord to various parts of the body, including muscles, organs and sensory receptors and vice versa. PNS is implicated in various medical conditions, from chronic pain to depression and epilepsy. Funded by the Marie Skłodowska-Curie Actions programme, the uOECT project aims to develop highly advanced soft neural probes for precise interfacing with the PNS to manage these conditions. To overcome technological limitations associated with existing solutions, the project will develop miniaturised, ultra-soft probes that can record neural activity with high spatial resolution. Moreover, these probes will be implantable with minimal tissue damage and immune reactivity.
Objective
This project is aimed at developing active soft neural probes for high-resolution, high-density interfacing of the peripheral nervous system (PNS). The availability of high-resolution PNS interfaces is key to the treatment and management of a number of common medical conditions such as neuropathic and chronic pain, paralysis, major depression, and epilepsy. Two major challenges that hinder progress in this area are: i) Mechanical mismatch between the neural tissue and the conventionally used neural probe materials (e.g. metal wires). ii) The electrode density and spreading is limited by the use of passive linear probes. This project seeks to address both these issues by developing miniaturized inert, ultra-soft (E<50kPa) multi-headed probes, which can be actuated in situ to record from a large volume of the neural tissue with high spatial resolution. This is combined with integration of multiple active neural transducer elements and integrated amplification circuitry for high signal fidelity and integrated multiplexing circuitry for addressing, into each probe arm. This approach simultaneously increases spatial resolution and signal fidelity of neural interfacing, while enabling chronic implantability due to decreased chronic immune response and scarring through the inert and mechanically compliant nature of the probes, as well as minimized tissue damage during implantation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
581 83 Linkoping
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.