Project description
South African plants to combat multidrug-resistant bacteria
Multidrug-resistant bacteria are becoming increasingly common causes of acute and chronic infections, posing a severe threat to public health worldwide, especially since antibiotics can cause many side effects. The problem is caused because when bacteria live together in a biofilm community, they tend to develop resistance to various types of antibiotics. The MSCA-funded INSAPANT project aims to use South African plants to synthesise biogenic nanoparticles to combat biofilms associated with these bacteria. The project's novel delivery system uses aptamers to selectively carry the nanoparticles to the site of action, making it more efficient. The findings could lead to a unique drug delivery system that reduces mortality caused by bacterial infections.
Objective
Multidrug-resistant bacteria are becoming implicated more frequently in acute and chronic infections. Bacteria often live together in a biofilm community, which makes it easier for bacteria to become resistant to different classes of antibiotics. This poses a severe threat to global public health, and the fact that antibiotics have many side effects makes the situation even worse. It is imperative to search for novel, safe, and effective antimicrobial agents and robust drug delivery strategies. In INSAPANT, South African plants will be employed for the green synthesis of biogenic nanoparticles, and their antibacterial potential against biofilm associated with multidrug-resistant bacteria will be investigated.
The main goal of the INSAPANT is to exploit a synergic therapeutic approach by designing a novel delivery system targeted with aptamers that will carry the biogenic nanoparticles selectively on site of action and protect them following systemic administration. This combinatorial strategy can potentially remove the biofilm in a manner that is more efficient than a passive release or the administration of the content alone.
INSAPANT has significant social benefits since it has the potential to lead to the creation of a unique drug delivery system for the treatment of biofilm formation and, ultimately, the reduction of mortality caused by bacterial infections.
The INSAPANT fellowship will contribute to i) Expose the researcher to a multidisciplinary and intersectoral research network and foster excellence in research; ii) Improve the researcher's project management and fundraising skills; iii) Enhance the researcher's communication, dissemination, and exploitation of results, as well as Transfer of Knowledge to various audiences; and iv) Boost the researcher's career development skills.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- social sciences sociology demography mortality
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- engineering and technology nanotechnology nano-materials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
66100 Chieti
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.