Project description
Non-invasive neuromodulation to treat Parkinson’s Disease
Neurological diseases such as Parkinson’s impair the motor control and quality of life of those afflicted. Treatment often involves invasive deep brain stimulation and pharmacotherapy. Recent studies attribute motor disorders to abnormal neural oscillations. Therefore, insight into the rhythms of the central nervous system could lead to more effective treatment approaches. Supported by the Marie Skłodowska-Curie Actions programme, the RhythMods project aims to create a non-invasive neuromodulation platform that uses closed-loop stimulation protocols synchronised with brain oscillations decoded from peripheral muscle recordings. This enables exploration of the modulatory effects of brain-oscillations-dependent stimulation of the central neural system to treat motor symptoms and develop new methods to entrain and disrupt neural oscillations linked to Parkinson’s and other neurological diseases.
Objective
Neurological diseases, such as Parkinsons Disease (PD), are the leading cause of disability in the world. The role of brain rhythms has not been completely understood but evidence suggest that specific motor disorders may be linked to abnormal brain oscillations. Researching ways to modulate specific cortical motor rhythms could lead to discovering more effective approaches to treat patients with neurological disorders affecting their motor condition. However, our current understanding tools are insufficient to access and interact with this kind of neural activity. Non-invasive neuromodulation protocols such as transcutaneous Spinal Cord Stimulation (tSCS) are raising interest in recent years to induce changes in the Central Nervous System (CNS) that can lead to functional improvement, while the side effects and applicability limitations of invasive procedures are overcome. Better understanding the interaction between neuromodulation protocols and brain rhythms is crucial for the development of interventions targeting pathological circuits which can favour plastic changes and the restoration of impaired motor functions. In RhytMods, I will develop a non-invasive neuromodulation platform to apply closed-loop stimulation protocols synchronized with brain oscillations decoded from the periphery with muscle recordings (high-density electromyography, HD-EMG). The platform will allow to explore the modulatory effects of brain-oscillations-dependent stimulation of the CNS to treat motor symptoms and its potential to entrain and disrupt neural oscillations linked to motor recovery in patients with PD. This research has the potential to transform our understanding of neurological disorders with pathological brain oscillations and to develop new minimally invasive and cost-effective technologies to treat the motor symptoms in neural disorders.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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50009 Zaragoza
Spain
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