Objective
ModBioTerp aims to train 10 exceptional candidates in biochemistry, AI-guided enzyme modeling, laboratory-directed evolution, and synthetic biology. The focus of this project is on the natural product class of terpenoids, which are the largest and most chemically diverse class of natural products and hold immense potential for biotechnological applications. With the latest EU policy on critical technologies from September 2023, which includes biotechnology and specifically mentions synthetic biology, ModBioTerp is well-poised to address these challenges. Terpene synthases (TPSs) are the enzymes responsible for generating the structural diversity found among terpenoid natural products. These elegant enzymes mediate complex carbocation-based cyclization and rearrangement cascades with various electron-rich linear and cyclic substrates. Terpenes are abundant in plants, bacteria, and fungi, and also form the basis of all life through sterols and other very basic metabolites. The biochemistry of terpene synthases is at the core of ModBioTerp with the focus on the challenge of translating a given enzyme model into the understanding of the product profiles of terpene synthases and providing a strong product prediction tool based on the enzyme models developed. The project will explore and exploit the chemical and biological diversity of terpenoids and develop a new fundamental biochemical understanding of these enzymes, ensuring the technological leadership of Europe. With this project, we will unlock the vast potential of terpenoids and lead the way toward sustainable and innovative biotechnological solutions. In ModBioTerp 10 Doctoral candidates (DCs) will spend their research and training time in academic and industrial groups, that are global leaders in the field of terpenoid biochemistry and enzyme modeling. All DCs will also spend time with secondment partners to learn new techniques and be immersed in different scientific environments.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences microbiology mycology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
42100 SAINT-ETIENNE
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.