Project description
Metalloenzymes to mitigate climate change
New and effective nature-based strategies are needed to help avert the looming climate catastrophe. With the support of the Marie Skłodowska-Curie Actions programme, the McGEA project aims to develop nature-inspired strategies to mitigate climate change. The project will use metalloenzymes as robust biocatalysts to address three critical environmental issues: CO2 capture, (bio)hydrogen production, and wastewater monitoring and remediation. It will focus on developing hybrid materials and live bacterial cells to carry and regenerate the metalloenzymes. The project involves research groups from both the EU and overseas, aiming to integrate fundamental scientific discovery with metalloenzyme-based processes and prototype devices through staff secondments to build diverse skills.
Objective
"""By far, nature is the best chemist of all time"" according to Nobel Prize winner Frances Arnold. McGEA will develop nature inspired strategies to help avert the pending climate catastrophe. We will discover, characterize, engineer and exploit metalloenzymes as potent biocatalysts to efficiently perform chemically challenging reactions of high environmental impact. Specifically, we will use metalloenzymes to tackle three burning issues that fall squarely in the remit of the EU Green Deal action plan: CO2 capture, (bio)hydrogen production, and wastewater monitoring and remediation. These challenges will be addressed using purified metalloenzymes incorporated into hybrid materials and live bacterial cells as self-regenerating catalytic metalloenzyme carriers. Implementation of these two strategies will proceed with research activities across the full pipeline of metalloenzyme development. This will include i) the assembly of the metallic co-factors, as a prerequisite for establishing protocols for efficient metalloenzyme production, ii) rational redesign, directed evolution and in silico strategies to develop enzyme variants that show improved catalytic activity and stability, and iii) the incorporation of the enzymes into matrices that allow for enzyme reusability, stabilization, or their self-assembly into multi-enzymatic nanostructures for substrate channeling. The execution of this program relies on a strong interdisciplinary and intersectoral team. The McGEA brings together 6 research groups from EU and 2 research groups from overseas, all of them internationally recognized for their scientific excellence, and 3 EU companies that will join forces to accelerate the transition to a climate-neutral Europe. The consortium is designed to provide a diverse portfolio of skills through staff secondments to achieve integration from the stages of fundamental scientific discovery to the development of metalloenzyme-based processes and prototype devices."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology environmental engineering water treatment processes wastewater treatment processes
- natural sciences chemical sciences catalysis biocatalysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff Exchanges
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-SE-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1099-085 Lisboa
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.