Project description
Skull fixated stimulation hubs for neurological disorder treatment
Deep brain stimulation (DBS) is a key treatment for neurological diseases for the ageing population. However, there is a need for less invasive alternatives. The BRAINET project consortium has identified spatio-temporal interference stimulation (stIS), a method using pairs of electrodes to precisely target and activate brain rhythms in therapeutic areas without the need for deep brain implantation. With the support of the Marie Skłodowska-Curie Actions programme, BRAINET will develop skull fixated stimulation hubs that create a communication network for therapeutic stimulation. These hubs will use innovative magneto-electrical transducers, powered by external magnetic fields, and advanced electrodes that barely come in contact with the brain. It will also equip researchers with the skills to enhance neurotechnology.
Objective
Invasive Deep Brain Stimulation (DBS) has become an important way to treat neurological diseases within the greying European society making a tether-less improvement desireable.
The BRAINET team is convinced to have identified such an alternative in spatio-temporal Interference Stimulation (stIS). stIS avoids implantation into the brain and uses instead pairs of electrodes to precisely target activating beating rhythms in the depth of the brain at the therapeutic region, without requiring deep seated electrodes. In order to unleash this stimulation power in all regions of the brain, BRAINET sets out to develop skull implantable stimulation hubs which build a communication network and 3D targeting by self-organization, providing semantic information transfer and synchronization, and thus enabling virtual, self-adjusting pairs for therapeutic stIS. These stimulation hubs will be powered by novel magneto-electrical transducer stacks, driven by slowly alternating magnetic fields from the outside and will perform adjustable frequency stimulation by novel nano-modified, compliant electrodes only touching the brain. Network formation will be enabled by multiphysics approaches and ionic in-body communication instantiated in dedicated microelectronic hardware. Preclinical in-vitro and in-vivo testing of devices and methods will allow the community to make important steps towards subsequent clinical implementation of our „Wireless Transcalvarial Brain Stimulators“. BRAINET will allow us to prepare the next generation of researchers, arming them with the knowledge, skills, and visionary insights necessary to drive neuro-technology to replace the present DBS into uncharted, but reliably safer and more flexible territories. BRAINET is an engine for excellence, interdisciplinary convergence, and innovation. Its dual mandate is to establish a training network and thus to lay the groundwork for emerging leaders.
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
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(opens in new window) HORIZON-MSCA-2024-DN-01
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79106 Freiburg
Germany
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Participants (8)
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D02 CX56 Dublin
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CO4 3SQ Colchester
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79098 Freiburg
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X91 K0EK Waterford
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21073 Hamburg
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98693 Ilmenau
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33100 Tampere
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4704 553 Braga
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Partners (8)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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98693 Ilmenau
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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4521 SCHIEDLBERG
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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72770 Reutlingen
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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6020 INNSBRUCK
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9220 Aalborg
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78153 Le Chesnay Cedex
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112 51 ATHINA
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2628 CN Delft
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