Project description
Revolutionizing Osteoarthritis Care: Crafting Superior Joint Solutions
Osteoarthritis (OA) affects millions of people worldwide, and current treatment often fails to repair lost cartilage, with patients resorting to joint replacement. Emerging tissue-engineering developments are on the horizon, but functional long-term regeneration is an issue. Supported by the Marie Skłodowska-Curie Actions programme, the RENOVATE project aims to combine multinational, multidisciplinary research with training to develop osteochondral scaffolds to treat extensive cartilage defects. Specifically, the project will draw on patient-specific data to optimise scaffold function, mechanical properties, and biological function, and to improve 3D printing technologies for graded, multi-material structures. It will train future biomedical engineers and clinicians, bridging academic and clinical disciplines, and empower them with cutting-edge skills, advancing OA therapy and inspiring regenerative-medicine careers.
Objective
Recent breakthroughs in tissue engineering are helping to overcome some severe limitations of osteoarthritis (OA) treatment strategies. Although the latest advances to regenerate cartilage lesions to a healthier state have opened a promising way to prevent joint replacement, current solutions still have a number of challenges ahead to effectively promote satisfactory durable regeneration along the disease progression. With these perspectives, the biomedical engineering market is rapidly growing and demands new knowledge, new skills and new approaches to adapt to the technological evolution of the sector while providing robust products, solutions and treatment strategies which only find a partial match in existing doctoral programmes. RENOVATE addresses this challenge by delivering an innovative multinational, multi sectoral, and multidisciplinary research and training programme in new technologies and novel strategies to produce a new generation of multi-material graded osteochondral scaffolds with a focus on large OC defects. From the research point of view, RENOVATE will integrate data and knowledge to: 1) define patient-specific key functional and mechanical requirements for large osteochondral scaffolds and deliver new therapeutic schemes; 2) enhance the physicochemical and biological behaviour and the mechanical fixation scaffolds; and 3) produce Functionally Graded large osteochondral scaffolds evolving existing 3D printing equipment. With this purpose, RENOVATE’s partnership aggregates relevant scientists from the academic and clinical worlds that will be involved in a high-level personalised training programme that will guarantee fellows and future PhD students outstanding Career Opportunities in the biomedical engineering, orthopaedic sectors and beyond. RENOVATE will disseminate results to a wide spectrum of stakeholders, create awareness in the general public about OA and encourage vocational careers among students.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
35001 Las Palmas De Gran Canaria
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.