Project description
Immune mechanisms across the tuberculosis spectrum
Tuberculosis (TB) is not a uniform disease but encompasses a spectrum of symptoms, ranging from latent infection with no symptoms to subclinical stages and active disease. Understanding how the immune system interacts with Mycobacterium tuberculosis across this spectrum is essential for predicting disease progression and for developing improved diagnostics. With the support of the Marie Skłodowska-Curie Actions programme, the TB-SPECTRUM project will bring together a multidisciplinary international consortium to investigate the immune mechanisms underlying TB spectrum transitions. The key objective is to identify biomarkers of disease progression, enhance translational research capacity and strengthen innovation in the field.
Objective
TB-SPECTRUM aims to strengthen international research collaboration among different sectors and disciplines, and to structure a network to perform high-quality, translational, and multidisciplinary research for (i) a better understanding of tuberculosis (TB) spectrum immune mechanisms; and (ii) increasing the capacities of the involved staff fostering training and networking activities, as well as increasing their inter-sectoral employability opportunities. Understanding the host-pathogen interactions in the different phases of the spectrum is fundamental for detecting biomarkers of disease progression that can lead to new diagnostic approaches for identifying those individuals with a high-risk of developing disease if infected or for detecting subclinical TB forms. However, it is still unknown which immunological mechanisms are involved in infection/disease progression. To unravel this knowledge gap, it is mandatory to develop collaborative research which combines different expertise in the TB field (clinics, diagnostics, treatment, clinical studies management, cellular/humoral immunology, genomics, and technology transfer, among others). For that purpose, a Consortium of nine academic and non-academic Institutions harboring TB-renowned experts has been constituted. This network is formed by specialists in the clinical management of active TB cases and their contacts (from high and low incident countries); experts in basic/applied science; and a small and medium-sized enterprise (SME) involved in the development of immune assays. Altogether, the proposed goals will be achieved through secondments among the different sectors, which will be extremely important for progressing to a better understanding of the requirements needed in TB management and control; and will expose participants to new research environments that will reinforce multidisciplinarity. Moreover, the interaction with an SME will improve knowledge transference skills, stimulating entrepreneurship.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff Exchanges
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-SE-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
08916 Badalona Barcelona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.