Project description
Pathway to isochalcogenourea catalysts and beyond
Recent advancements in photocatalysis have resulted from the development of tunable photocatalysts and affordable energy sources, such as sunlight. There is increasing interest in combining organocatalysis with photocatalysis for dual catalytic transformations. However, the lack of efficient methods for utilising cheap feedstock chemicals in carboxylic acid oxidation has limited their applications. Supported by the Marie Skłodowska-Curie Actions programme, the PhotoCat project will design a scalable pathway to manufacturing novel conformally constrained photostable isochalcogenourea catalysts. Using these catalysts, the project will develop a revolutionary dual photocatalytic isomerisation process for the synthesis of fine chemical products.
Objective
In recent years applications of photocatalysis have developed rapidly, with the use of an abundant, cheap energy source (the sun or ambient light) combined with the development of tunable photocatalysts, allowing the facile generation of radicals via single electron transfer or excited state intermediates via energy transfer. Organocatalysis uses small organic molecules to promote enantioselective reactions and has been widely applied over the last two decades for the synthesis of enantioenriched products, with the 2022 Nobel Prize for Chemistry awarded for demonstrating the power of this methodology by MacMillan and List. Combining these two methods in dual catalytic transformations has been demonstrated, however the ability to promote such transformations that utilise abundant and cheap feedstock chemicals at the carboxylic acid oxidation level is a significant challenge, typically requiring tertiary amine Lewis base catalysts. However, utilising enantiopure tertiary amines with photocatalytic transformations is currently limited, due to the facile oxidation and subsequent degradation of the tertiary organocatalyst by the excited state photocatalyst.
In this context. this proposal will:
1. Deliver a scalable route to conformally constrained photostable isochalcogneourea catalysts based upon conformationally locked bicyclic catalysts that do not allow traditional oxidative degradation.
2. Utilise these isochalcogneourea catalysts to develop a dual photocatalytic isomerization of (E)-enone acids to their contra-thermodynamic (Z)-isomers followed by isochalcogenourea promoted acylative DKR for the synthesis of fine chemical products. This will be applied to the synthesis of 5- and 7 membered ring compounds as well as the synthesis of planar chiral species.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences catalysis photocatalysis
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences chemical sciences organic chemistry amines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
KY16 9AJ ST ANDREWS
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.