Project description
Personalised risk stratification for rare cardiac arrhythmias
Brugada syndrome (BrS) is an inherited heart condition associated with abnormal electrical activity that can trigger sudden ventricular fibrillation. Current patient stratification relies on statistical scores rather than biomarkers, which do not reliably predict the risk of sudden cardiac arrest in asymptomatic patients. With the support of the Marie Skłodowska-Curie Actions programme, the Br-TRAP project aims to address this unmet clinical need by developing patient-specific computational simulations of heart electrophysiology to simulate arrhythmia onset. By calibrating the model using patient-specific electrocardiography data, Br-TRAP will shift risk stratification to a personalised diagnostic approach.
Objective
The Br-TRAP project addresses the current gap in risk stratification for asymptomatic patients affected by Brugada Syndrome (BrS). BrS is an electrophysiological (EP) disease that manifests in a localized substrate in the right ventricular outflow tract of patients, generating a specific ECG pattern in V1-V2 leads. BrS is associated to sudden presentation of ventricular fibrillation (VF) in patients, to date risk stratification is based on risk scores and severely underperforms in asymptomatic cohorts due to lack of significant risk markers.
Br-TRAP uses computational simulations of cardiac EP to define a patient specific virtual BrS substrate and use it to simulate the onset of arrhythmia and infer the conditions that precipitate VF in BrS patients. The substrate will be validated with experimental data and will be used to identify arrhythmic risk for each condition.
Then, the virtual substrate will be embedded into an anatomically accurate torso and heart to calibrate the model using patient specific ECG. By establishing a relationship between surface leads and BrS substrate, risk stratification becomes patient specific and mechanistically driven.
Br-TRAP will output two innovative results. First, the virtual substrate will be a software platform to generate virtual EP experiments that fosters standardization and reproducibility of computational results, while also lowering the degree of expertise needed to perform complex computational simulations. Second, the calibration methods used to tailor the virtual substrate to patient specific data will provide a innovative pipeline that mechanistically link common clinical measures with information that can only be acquired invasively.
Br-TRAP shifts risk stratification from a primarily statistical approach to a personalized one centered on identifying the causes of VF in each patient. This paradigm shift adds new information to current diagnostic procedures and opens a new approach to substrate based diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine cardiology cardiovascular diseases cardiac arrhythmia
- natural sciences computer and information sciences software
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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(opens in new window) HORIZON-MSCA-2025-PF
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8010 Graz
Austria
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