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TICKGUARD — Gateway surveillance as an early warning system for emerging tick-borne pathogens in Europe

Project description

Migratory sentinels: monitoring avian and livestock tick pathogens

Tick-borne pathogens are a growing health threat, often present in livestock before triggering human outbreaks. Because Crete sits at the crossroads of three continents and is a major stopover for migratory birds, it is a high-risk gateway for exotic diseases entering Europe. Supported by the Marie Skłodowska-Curie Actions programme, the TICKGUARD project aims to address this by developing rapid, portable diagnostic tools to detect five priority pathogens directly in the field. Researchers will test thousands of animals and birds, comparing new portable tests with laboratory standards while using genetic sequencing to track invasive tick species. By creating geospatial maps of these threats, the project is expected to strengthen Europe’s early-warning systems, enabling proactive, evidence-based action against emerging infectious diseases.

Objective

Tick-borne pathogens represent an escalating One Health challenge, often persisting asymptomatically in livestock and wildlife before causing outbreaks in animals or humans. Crete’s geographic position—at the intersection of Europe, Asia, and Africa—and its role as a major stopover for migratory birds, particularly on Gavdos Island, makes it a natural entry point for exotic and emerging pathogens into Europe. Targeted surveillance in this high-risk gateway offers a unique early-warning opportunity, enabling the detection of threats before they spread northwards or westwards.
This fellowship will develop and validate portable, rapid molecular diagnostics for five priority agents—Crimean-Congo haemorrhagic fever virus (CCHFV), tick-borne encephalitis virus (TBEV), Anaplasma spp., Babesia spp., and Theileria spp.—using the Pebble nucleic acid amplification device. Ticks and blood samples from 1,800 sheep and goats and from 1,000 wild and migratory birds, will be analysed using both Pebble-based LAMP assays and laboratory-based qPCR/multiplex PCR, enabling a direct performance comparison. Morphological and molecular identification of ticks will detect invasive species and monitor shifts in local populations, while next-generation sequencing will characterise phylogenetic relationships between tick populations and pathogens from neighbouring regions, with a specific focus on circulating CCHFV genotypes and Hyalomma spp. phylogenomics. These results will be integrated into geospatial prevalence maps, enhancing Europe-wide early-warning systems.
By integrating diagnostic innovation, high-risk gateway surveillance, and stakeholder engagement, TICKGUARD will strengthen Europe’s capacity for proactive, evidence-based action against transboundary zoonotic threats.

Fields of science (EuroSciVoc)

Keywords

Programme(s)

Topic(s)

Funding Scheme

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

(opens in new window) HORIZON-MSCA-2025-PF

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Coordinator

IDRYMA TECHNOLOGIAS KAI EREVNAS
Net EU contribution
€ 197 263,68
Address
N PLASTIRA STR 100
700 13 IRAKLEIO
Greece
Region
Νησιά Αιγαίου Κρήτη Ηράκλειο
Activity type
Research Organisations
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Total cost
No data

Partners (1)