Project description
Machine learning to identify neural signatures of resilience in youth
Problems in early life, including adverse childhood experiences (ACEs) such as abuse and household instability, as well as chronic pain, may result in lasting effects. On the bright side, many children exhibit an impressive degree of resilience. However, the biological basis for this resilience is not yet fully understood. Supported by the Marie Skłodowska-Curie Actions programme, the BRAVA project is designed to fill this knowledge gap. Using machine learning technologies and brain scans of numerous teenagers, the project aims to identify brain biomarkers of resilience. These developments are essential for identifying vulnerable youth and providing support.
Objective
Adversity in youth poses a serious threat to long-term health and well-being, causing immense suffering and overwhelming healthcare systems. Two major sources of adversity in youth are adverse childhood experiences (ACEs), such as abuse or neglect, and chronic health conditions, such as chronic pain (CP). ACEs double the risk of psychiatric disorders, while CP in youth has severe long-term consequences, affecting all aspects of life and often persisting into adulthood. However, over 60% of youth exposed to ACEs and 20-40% of youth with CP demonstrate resilience: the capacity to withstand adversity and maintain optimal psychosocial functioning. Despite its protective role, the neurobiological mechanisms that predict and support the development of resilience remain to be elucidated. BRAVA will address this gap using a falsifiable, hypothesis-driven approach that leverages machine learning (ML) and readily available, large samples of adolescents to develop the first brain markers that predict resilience to ACEs and to CP at the individual level. BRAVA will identify and compare the neurobiological mechanisms promoting resilience to ACEs and to CP in adolescents in a developmentally attuned manner. This will be achieved through an interdisciplinary and international collaboration between pioneers in ML applied to large-scale, longitudinal datasets (McGill University, outgoing phase) and in the neurobiology of CP in youth (University of Barcelona, return phase). My expertise in pediatric neuroimaging incorporating developmental and social psychology perspectives, as well as my capacity to foster interdisciplinary and international collaborations, make me the perfect fit to lead this project. The excellent training plan will enhance my ability to conduct high-impact research independently. BRAVA’s synergies are set to transform our understanding of resilience and provide actionable and accessible tools to identify at-risk youth and inform personalized interventions.
Fields of science (EuroSciVoc)
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
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(opens in new window) HORIZON-MSCA-2025-PF
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08007 Barcelona
Spain
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