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Brain Predictors of Resilience to Adversity in Adolescence

Descrizione del progetto

L’apprendimento automatico per identificare le caratteristiche neurali della resilienza nei giovani

I problemi vissuti nella prima infanzia, tra cui le esperienze avverse dell’infanzia (AVI) come gli abusi e l’instabilità familiare, nonché il dolore cronico, possono avere effetti duraturi. D’altro canto, molti bambini mostrano un notevole grado di resilienza, ma le sue basi biologiche non sono ancora del tutto comprese. Sostenuto dal programma di azioni Marie Skłodowska-Curie, il progetto CyaSafe si prefigge di colmare questa lacuna di conoscenze. Usando tecnologie di apprendimento automatico e scansioni cerebrali di numerosi adolescenti, si propone di identificare i biomarcatori cerebrali della resilienza. Questi sviluppi sono essenziali per individuare i giovani vulnerabili e fornire loro un sostegno.

Obiettivo

Adversity in youth poses a serious threat to long-term health and well-being, causing immense suffering and overwhelming healthcare systems. Two major sources of adversity in youth are adverse childhood experiences (ACEs), such as abuse or neglect, and chronic health conditions, such as chronic pain (CP). ACEs double the risk of psychiatric disorders, while CP in youth has severe long-term consequences, affecting all aspects of life and often persisting into adulthood. However, over 60% of youth exposed to ACEs and 20-40% of youth with CP demonstrate resilience: the capacity to withstand adversity and maintain optimal psychosocial functioning. Despite its protective role, the neurobiological mechanisms that predict and support the development of resilience remain to be elucidated. BRAVA will address this gap using a falsifiable, hypothesis-driven approach that leverages machine learning (ML) and readily available, large samples of adolescents to develop the first brain markers that predict resilience to ACEs and to CP at the individual level. BRAVA will identify and compare the neurobiological mechanisms promoting resilience to ACEs and to CP in adolescents in a developmentally attuned manner. This will be achieved through an interdisciplinary and international collaboration between pioneers in ML applied to large-scale, longitudinal datasets (McGill University, outgoing phase) and in the neurobiology of CP in youth (University of Barcelona, return phase). My expertise in pediatric neuroimaging incorporating developmental and social psychology perspectives, as well as my capacity to foster interdisciplinary and international collaborations, make me the perfect fit to lead this project. The excellent training plan will enhance my ability to conduct high-impact research independently. BRAVA’s synergies are set to transform our understanding of resilience and provide actionable and accessible tools to identify at-risk youth and inform personalized interventions.

Campo scientifico (EuroSciVoc)

Parole chiave

Programma(i)

Argomento(i)

Meccanismo di finanziamento

HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships

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Invito a presentare proposte

(si apre in una nuova finestra) HORIZON-MSCA-2025-PF

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Coordinatore

UNIVERSITAT DE BARCELONA
Contributo netto dell'UE
€ 318 138,72
Indirizzo
GRAN VIA DE LES CORTS CATALANES 585
08007 Barcelona
Spagna
Regione
Este Cataluña Barcelona
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato

Partner (1)