Objective
Acute brain diseases like stroke and ischemia (as seen in cardiac arrest) as well as chronic degenerative brain disorders like epilepsy, Alzheimer's disease and Huntington's disease have immense consequences both socioeconomically and individually. It has been suggested that these diseases are linked to abnormal extracellular concentrations of the excitatory neurotransmitter glutamate in the brain. It is of vital importance to establish whether this is true or not to pave the way for pharmaceutical research aimed at rescuing brain cells at risk of degeneration. Inactivation of glutamate is achieved by uptake into nerve cells or glia. The project will use molecular biological techniques (gene targeting) to develop mice without neuronal or glial uptake mechanisms to study the importance of such uptake mechanisms for the survival of nerve cells in animal models of stroke, epilepsy and chronic neurodegeneration.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology epilepsy
- medical and health sciences basic medicine neurology neurodegenerative diseases dementia alzheimer
- medical and health sciences basic medicine neurology stroke
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 4AT Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.