Skip to main content
Vai all'homepage della Commissione europea (si apre in una nuova finestra)
italiano it
CORDIS - Risultati della ricerca dell’UE
CORDIS
Contenuto archiviato il 2024-06-10

Inactivation of the excitatory neurotransmitter glutamate. Its role in acute and chronic neurodegeneration

Obiettivo



Acute brain diseases like stroke and ischemia (as seen in cardiac arrest) as well as chronic degenerative brain disorders like epilepsy, Alzheimer's disease and Huntington's disease have immense consequences both socioeconomically and individually. It has been suggested that these diseases are linked to abnormal extracellular concentrations of the excitatory neurotransmitter glutamate in the brain. It is of vital importance to establish whether this is true or not to pave the way for pharmaceutical research aimed at rescuing brain cells at risk of degeneration. Inactivation of glutamate is achieved by uptake into nerve cells or glia. The project will use molecular biological techniques (gene targeting) to develop mice without neuronal or glial uptake mechanisms to study the importance of such uptake mechanisms for the survival of nerve cells in animal models of stroke, epilepsy and chronic neurodegeneration.

Campo scientifico (EuroSciVoc)

Programma(i)

Argomento(i)

Invito a presentare proposte

Dati non disponibili

Meccanismo di finanziamento

RGI - Research grants (individual fellowships)

Coordinatore

The Babraham Institute
Contributo UE
Nessun dato
Indirizzo

CB2 4AT Cambridge
Regno Unito
Costo totale
Nessun dato

Partecipanti (1)