Objective
Proteasomes are essential components of eukaryotic cells and have also been found in prokaryotes. They play a key role in intracellular protein degradation and are composed of related subunits which fall into two families, named a- and B-type subunits.
A general feature of all proteasome B-type subunits is a highly variable prosequence. We plan to explore the role of the B propeptide in the activation and assembly mechanisms of the Rhodococcus prokaryotic proteasome. It is an extremely useful research tool because it displays an intermediate complexity between the archaebacterial and eukaryotic complexes. A prime focus of our work will be to elucidate the mechanisms involved in the cleavage of the prosequence. The other major goal will be to investigate the potential role of the prosequence in targeting a B subunit to its a partner. These investigations will be performed by using multidisciplinary approaches combining recombinant DNA techniques, site-directed mutagenesis and electron microscopy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy electron microscopy
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
82152 MARTINSRIED
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.