Objective
In the last decades isolation and screening of natural products has become a very important factor in finding new therapeutic agents. During this project a synthesis for the Galbulimima Alkaloids Himgravine 7 and Himbacine 8 should be developed. These Alkaloids should stimulate the release of acethylcholin and due to the cholinergic hypothesis should alleviate the symptoms for Alzheimer's disease. A retrosynthetic approach, as illustrated in scheme 1, shows that suitable building blocks can be prepared starting with substrates from the chiral pool like amino acids, lactic acid 1 as well as heterocycles 6 by using various standard organic reactions (C-C coupling reactions, protection and deprotection of functional groups and stereoselective synthesis). Modern analytical methods like HPLC, GC, NMR-, IR- and Masspectrometrie will be used to identify the intermediates and products.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences chemical sciences organic chemistry organic reactions
- natural sciences chemical sciences organic chemistry organic acids
- natural sciences chemical sciences organic chemistry amines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OX1 3QY OXFORD
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.