Objective
In this project we intend to further characterise the structure and function of the snoRNP (small nucleolar ribonucleoparticle) snR30. This particle, made of the essential snoRNA (small nucleolar RNA) snR30 and several nucleolar proteins, has been shown to be required for the ribosomal processing reactions which lead to the formation of the mature 18S rRNA, the RNA component of the small ribosomal subunit.
We propose to identify new genes whose products either interact or have overlapping functions with the snoRNA snR30. This will be achieved through the isolation of multicopy and extragenic suppressors of snr30 conditional mutations, as well as the identification of synthetic lethal mutations. This screening should allow the identification of proteins associated with the snR30 RNP particle, as well as interactions between different snoRNP particles. This will provide a test of current hypotheses for mechanisms involved in pre-rRNA processing in yeast.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics RNA
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EH9 3Jr EDINBURGH
United Kingdom
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