Objective
The objective of our project is to set up an experimental model allowing the in vivo study of the functions of HLA-E molecules. With this aim, we have produced eight HLA-E transgenic mouse lines. The research programme will study: (i) the expression of HLA-E molecules, (ii) their role as transplantation antigens (skin graft rejection, bone marrow transplantation and graft versus host reaction), (iii) their antigen presentation capacity, (iv) their immunogenicity for B and T cells, (v) their influence on tumor growth, i.e. their possible role in immunosurveillance. In addition, the model opens up the possibility to produce HLA-E specific monoclonal antibodies, an essential and still missing tool for the detection of these molecules.In summary, the results of these experiments should contribute to the elucidation of the physiological significance and the role in transplantation of the abundant family of human nonclassical class I molecules.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75010 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.