Objective
The Taxol family of molecules has commanded the attention of the most important synthetic organic chemists due to their unusual tetracyclic structure and, more importantly, to their potent anti-cancer properties. In this project it is intented to develop a new synthetic strategy towards this family of compounds, in which two major fragments are coupled at a late stage in the sequence, and Band C-rings are cyclised in a single step via cation-mediated cascade cyclisation. The cyclohexenyl A-ring acts as a spacer group between the oxetane D-ring acetal and the nucleophilic propargylic silane terminator.
The termodynamic driving force for the sequential C-C bond formation will be as a result of formation of increasingly stabilised carbocationic species down the cascade. The novelty of this strategy lies in the cyclisation of a precursor containing intact A and D rings to form B and C rings.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SW7 2AZ LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.