Objective
The instigation of a multidisciplinary approach to the analysis of cellular controlled genetic programmes that are regulated by extracellular stimuli. signalling mechanisms merges biophysical, cell biological, molecular biological, and genetic techniques towards a common goal. This integrated These stimuli activate intracellular cascades which transduce signals to approach to solving an important cellular signalling problem will provide the nuclei and modulate transcription factor function and gene activity. a broad and expert knowledge base that will teach young scientists an These cascades are wired into very complex interconnected networks of extensive range of different techniques in modern biology in a signalling pathways and are largely driven by second messenger systems and by the enzymatic activities of protein kinases and protein phosphatases. goal-oriented manner.
Misregulation of signalling networks is a major cause of cell malfunction and disease. .
We propose to set up a TMR network that will instigate a coordinated multidisciplinary dissection of the complex signalling pathways that regulate gene activity during cell proliferation and differentiation. We will use:
(i) biochemical techniques to analyse enzymatic reactions in signal transduction,
(ii) biophysical methods to determine the molecular structures of the signal targets,
(iii) genetic approaches in Drosophila melanogaster, Mus musculus, and Saccharomyces cerevisiae to provide novel insights into signal cascades and
(iv) molecular studies to understand signal-dependent gene control.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
30623 Hannover
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.